4-(benzyloxycarbonyl-O-benzyl-L-tyrosyl)aminobutyryl-L-phenylalanyl-L-leucine

Base Information

Chemical Name:4-(benzyloxycarbonyl-O-benzyl-L-tyrosyl)aminobutyryl-L-phenylalanyl-L-leucine
CAS No.:80977-22-6
Molecular Formula:C₄₃H₅₀N₄O₈
Molecular Weight:750.892
Hs Code.:

Synonyms:4-(benzyloxycarbonyl-O-benzyl-L-tyrosyl)aminobutyryl-L-phenylalanyl-L-leucine

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Chemical Property of 4-(benzyloxycarbonyl-O-benzyl-L-tyrosyl)aminobutyryl-L-phenylalanyl-L-leucine

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Technology Process of 4-(benzyloxycarbonyl-O-benzyl-L-tyrosyl)aminobutyryl-L-phenylalanyl-L-leucine

There total 6 articles about 4-(benzyloxycarbonyl-O-benzyl-L-tyrosyl)aminobutyryl-L-phenylalanyl-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 80977-21-5
(S)-2-[(S)-2-(4-Amino-butyrylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

: 52773-66-7
benzyloxycarbonyl-O-benzyl-L-tyrosine 1-succinimidyl ester

: 80977-22-6
4-(benzyloxycarbonyl-O-benzyl-L-tyrosyl)aminobutyryl-L-phenylalanyl-L-leucine

Guidance literature:: In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1071/CH9812439

Reference yield:

: 86827-18-1,92455-53-3,16677-29-5
N-benzyloxycarbonyl-O-benzyl-L-tyrosine

: 80977-22-6
4-(benzyloxycarbonyl-O-benzyl-L-tyrosyl)aminobutyryl-L-phenylalanyl-L-leucine

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / N,N'dicyclohexylcarbodiimide / dioxane

2: 98 percent / dimethylformamide / Ambient temperature

With dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1071/CH9812439

Reference yield:

: 73994-87-3
(S)-benzyl 2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanoate hydrochloride

: 80977-22-6
4-(benzyloxycarbonyl-O-benzyl-L-tyrosyl)aminobutyryl-L-phenylalanyl-L-leucine

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / Et₃N / dimethylformamide / Ambient temperature

2: 91 percent / H₂ / 10percent Pd/C / methanol / 2 h

3: 76 percent / 40percent aq. CH₃NH₂ / 48 h / Ambient temperature

4: 98 percent / dimethylformamide / Ambient temperature

With hydrogen; triethylamine; methylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1071/CH9812439