H-Phe-Leu-OBzl·HCl

Base Information

• Chemical Name: H-Phe-Leu-OBzl·HCl
• CAS No.: 73994-87-3
• Molecular Formula: C22H28N2O3.ClH
• Molecular Weight: 404.937
• Mol file: 73994-87-3.mol

Synonyms:H-Phe-Leu-OBzl*HCl;REF DUPL: H-Phe-Leu-OBzl HCl;L-phenylalanyl-L-leucine benzyl ester hydrochloride;Phe-Leu-OBzl*hydrochloride;Phe-Leu-OBzl*HCl;HCl.H-Phe-Leu-OBzl;(S)-benzyl 2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanoate hydrochloride;HCl*Phe-Leu-OBzl;

Chemical Property of H-Phe-Leu-OBzl·HCl

Chemical Property:

• PSA: 81.42000
• LogP: 4.72390

Purity/Quality:

99% ^*data from raw suppliers

H-PHE-LEU-OBZL HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-Phe-Leu-OBzl·HCl

There total 12 articles about H-Phe-Leu-OBzl·HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-tert-butyloxycarbonyl-L-phenylalanyl-L-leucine benzyl ester (74193-68-3) → (S)-benzyl 2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanoate hydrochloride (73994-87-3)

Guidance literature:

With hydrogenchloride; In neat (no solvent, solid phase); for 2h;

DOI:10.1039/c3gc40302e

Reference yield:

tert-butoxycarbonyl-α-methyl-L-phenylalanyl-L-valine benzyl ester (74825-82-4) → (R)-2-((S)-2-Amino-3-phenyl-propionylamino)-4-methyl-pentanoic acid benzyl ester; hydrochloride (73994-87-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 3h;

DOI:10.1021/jm00184a010

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-benzyl 2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanoate hydrochloride (73994-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / TEA, DCC / CH₂Cl₂ / 1.) -10 deg C, 1 h, 2.) room temperature, 10 h

2: 93 percent / 4M HCl / dioxane / 0.5 h

With hydrogenchloride; TEA; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;

upstream raw materials:

L-Leucine benzyl ester

N-trityl-L-phenylalanine

dicyclohexyl-carbodiimide

N-tert-butyloxycarbonyl-L-phenylalanyl-L-leucine benzyl ester

Downstream raw materials:

Boc-Gly-Phe-Leu-OBzl

4-(phthaloyl)aminobutyryl-L-phenylalanyl-L-leucine benzyl ester

benzyloxycarbonyl-O-benzyl-L-tyrosyl-L-phenylalanyl-L-leucine benzyl ester

Boc-(OBzl)-Tyr-D-Ala-Gly-Phe-Leu-OBzl