1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one

Base Information

• Chemical Name: 1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one
• CAS No.: 1191250-88-0
• Molecular Formula: C₂₀H₂₁F₁₃O₂Si
• Molecular Weight: 568.45

Synonyms:1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one

Chemical Property of 1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of 1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one

There total 1 articles about 1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

n-perfluorohexyl iodide (355-43-1) + 4-(tert-butyldimethylsilyloxymethyl)benzoic acid methyl ester (139706-48-2) → 1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one (1191250-88-0)

Guidance literature:

n-perfluorohexyl iodide; With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h; Inert atmosphere;

4-(tert-butyldimethylsilyloxymethyl)benzoic acid methyl ester; In tetrahydrofuran; diethyl ether; at -78 - 0 ℃;

DOI:10.1021/ol901955y

Reference yield: 47.0%

1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one (1191250-88-0) + p-toluenesulfonyl chloride (98-59-9) → 1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one o-tosyl oxime (1191250-90-4)

Guidance literature:

1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one; With pyridine; hydroxylamine hydrochloride; In ethanol; at 20 - 85 ℃;

p-toluenesulfonyl chloride; With pyridine; In dichloromethane; at 85 ℃; for 16h;

DOI:10.1021/ol901955y

Reference yield:

1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one (1191250-88-0) → C20H23F13N2OSi

Guidance literature:

With ammonia; In ethanol; at -78 - 20 ℃; for 12h;

DOI:10.1021/ol901955y

upstream raw materials:

n-perfluorohexyl iodide

4-(tert-butyldimethylsilyloxymethyl)benzoic acid methyl ester

Downstream raw materials:

1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-one o-tosyl oxime

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