1-(6-{5-methyl-2-[2-(tetrahydofuran-3-yl)-1,2,3,4-tetrahydroisoquinolin-6-ylmethoxy]phenyl}pyridin-2-yl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:1-(6-{5-methyl-2-[2-(tetrahydofuran-3-yl)-1,2,3,4-tetrahydroisoquinolin-6-ylmethoxy]phenyl}pyridin-2-yl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid
CAS No.:1398411-39-6
Molecular Formula:C₃₁H₂₉F₃N₄O₄
Molecular Weight:578.591
Hs Code.:

1-(6-{5-methyl-2-[2-(tetrahydofuran-3-yl)-1,2,3,4-tetrahydroisoquinolin-6-ylmethoxy]phenyl}pyridin-2-yl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid

Synonyms:1-(6-{5-methyl-2-[2-(tetrahydofuran-3-yl)-1,2,3,4-tetrahydroisoquinolin-6-ylmethoxy]phenyl}pyridin-2-yl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-(6-{5-methyl-2-[2-(tetrahydofuran-3-yl)-1,2,3,4-tetrahydroisoquinolin-6-ylmethoxy]phenyl}pyridin-2-yl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-(6-{5-methyl-2-[2-(tetrahydofuran-3-yl)-1,2,3,4-tetrahydroisoquinolin-6-ylmethoxy]phenyl}pyridin-2-yl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid

There total 6 articles about 1-(6-{5-methyl-2-[2-(tetrahydofuran-3-yl)-1,2,3,4-tetrahydroisoquinolin-6-ylmethoxy]phenyl}pyridin-2-yl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₃F₃N₄O₄

: 1398411-39-6
1-(6-{5-methyl-2-[2-(tetrahydofuran-3-yl)-1,2,3,4-tetrahydroisoquinolin-6-ylmethoxy]phenyl}pyridin-2-yl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: C₃₃H₃₃F₃N₄O₄; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 50 ℃; for 14h;

With trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1128268-00-7
ethyl 1-(6-chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1398411-39-6
1-(6-{5-methyl-2-[2-(tetrahydofuran-3-yl)-1,2,3,4-tetrahydroisoquinolin-6-ylmethoxy]phenyl}pyridin-2-yl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 15 h / 80 °C

2.1: boron tribromide / dichloromethane / 3.83 h / 0 - 20 °C

3.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene; tetrahydrofuran / 14 h / 80 °C

3.2: 2 h / 20 °C

4.1: sodium cyanoborohydride; acetic acid / methanol / 16 h / 20 - 50 °C / 4 ? molecular sieve

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 14 h / 50 °C

With tributylphosphine; lithium hydroxide monohydrate; water; boron tribromide; sodium cyanoborohydride; sodium carbonate; acetic acid; 1,1'-azodicarbonyl-dipiperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; 1.1: Suzuki Coupling / 3.1: Mitsunobu reaction;

Reference yield:

: 622867-52-1
6-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 1398411-39-6
1-(6-{5-methyl-2-[2-(tetrahydofuran-3-yl)-1,2,3,4-tetrahydroisoquinolin-6-ylmethoxy]phenyl}pyridin-2-yl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene; tetrahydrofuran / 14 h / 80 °C

1.2: 2 h / 20 °C

2.1: sodium cyanoborohydride; acetic acid / methanol / 16 h / 20 - 50 °C / 4 ? molecular sieve

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 14 h / 50 °C

With tributylphosphine; lithium hydroxide monohydrate; water; sodium cyanoborohydride; acetic acid; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; toluene; 1.1: Mitsunobu reaction;