Ethyl 2-[1-[2-[8-chloro-6-(2-ethoxy-3-methoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl]4-piperidinyl]acetate

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Chemical Name:Ethyl 2-[1-[2-[8-chloro-6-(2-ethoxy-3-methoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl]4-piperidinyl]acetate
CAS No.:937056-44-5
Molecular Formula:C₃₂H₃₇ClN₂O₆
Molecular Weight:581.109
Hs Code.:

Synonyms:Ethyl 2-[1-[2-[8-chloro-6-(2-ethoxy-3-methoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl]4-piperidinyl]acetate

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Chemical Property of Ethyl 2-[1-[2-[8-chloro-6-(2-ethoxy-3-methoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl]4-piperidinyl]acetate

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Technology Process of Ethyl 2-[1-[2-[8-chloro-6-(2-ethoxy-3-methoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl]4-piperidinyl]acetate

There total 7 articles about Ethyl 2-[1-[2-[8-chloro-6-(2-ethoxy-3-methoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl]4-piperidinyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937058-82-7
ethyl (E)-[1-[3-[1-[4-chloro-2-[1-(2-ethoxy-3-methoxyphenyl)-1-hydroxymethyl]phenyl]-1H-pyrrol-2-yl]acryloxy]piperidin-4-yl]acetate

: 937056-44-5
Ethyl 2-[1-[2-[8-chloro-6-(2-ethoxy-3-methoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl]4-piperidinyl]acetate

Guidance literature:: ethyl (E)-[1-[3-[1-[4-chloro-2-[1-(2-ethoxy-3-methoxyphenyl)-1-hydroxymethyl]phenyl]-1H-pyrrol-2-yl]acryloxy]piperidin-4-yl]acetate; With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 63h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 937058-72-5
1-[4-Chloro-2-(2-ethoxy-3-methoxybenzoyl)phenyl]-1H-pyrrol-2-carbaldehyde

: 937056-44-5
Ethyl 2-[1-[2-[8-chloro-6-(2-ethoxy-3-methoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl]4-piperidinyl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 5 h / Heating / reflux

2.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

3.1: methanol; water; potassium carbonate / 3.5 h / 60 °C

4.1: benzotriazol-1-ol / dichloromethane / 0.17 h / 20 °C

4.2: 18 h / 20 °C

5.1: aluminum (III) chloride / dichloromethane / 63 h / 20 °C

With methanol; aluminum (III) chloride; sodium tetrahydroborate; water; potassium carbonate; benzotriazol-1-ol; In methanol; dichloromethane; toluene;

Reference yield:

: 66799-97-1
2-ethoxy-3-methoxybenzaldehyde

: 937056-44-5
Ethyl 2-[1-[2-[8-chloro-6-(2-ethoxy-3-methoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl]4-piperidinyl]acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / diethyl ether; hexane / 1.08 h / -78 - 20 °C

1.2: 1 h / -78 - 20 °C

2.1: manganese(IV) oxide / dichloromethane / 19.5 h / 20 °C / Heating / reflux

3.1: trichlorophosphate / 1,2-dichloro-ethane / 0.17 h / 0 - 20 °C

3.2: 3.5 h / 0 °C / Heating / reflux

3.3: 1 h / Heating / reflux

4.1: toluene / 5 h / Heating / reflux

5.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C

6.1: methanol; water; potassium carbonate / 3.5 h / 60 °C

7.1: benzotriazol-1-ol / dichloromethane / 0.17 h / 20 °C

7.2: 18 h / 20 °C

8.1: aluminum (III) chloride / dichloromethane / 63 h / 20 °C

With methanol; manganese(IV) oxide; aluminum (III) chloride; sodium tetrahydroborate; n-butyllithium; water; potassium carbonate; benzotriazol-1-ol; trichlorophosphate; In methanol; diethyl ether; hexane; dichloromethane; 1,2-dichloro-ethane; toluene;