(2R,3R)-3-(2-bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Base Information

Chemical Name:(2R,3R)-3-(2-bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CAS No.:1575609-66-3
Molecular Formula:C₁₉H₁₉BrF₂N₄OS
Molecular Weight:469.353
Hs Code.:

Synonyms:(2R,3R)-3-(2-bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

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Chemical Property of (2R,3R)-3-(2-bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

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Technology Process of (2R,3R)-3-(2-bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

There total 2 articles about (2R,3R)-3-(2-bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2-bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromide

: 124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

: 1575609-66-3
(2R,3R)-3-(2-bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: With lithium hydroxide monohydrate; In acetonitrile; at 80 ℃; for 24h;
DOI:10.1021/jm4016284

Reference yield:

: 230301-73-2
6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester

: 1575609-66-3
(2R,3R)-3-(2-bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: bromine / chloroform / 12 h / 30 °C

2: lithium hydroxide monohydrate / acetonitrile / 24 h / 80 °C

With lithium hydroxide monohydrate; bromine; In chloroform; acetonitrile;
DOI:10.1021/jm4016284

Reference yield: 61.6%

: 1575609-66-3
(2R,3R)-3-(2-bromo-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

: 5720-05-8
4-methylphenylboronic acid

: 1575609-77-6
(2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-methylphenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 80 ℃; for 10h; Inert atmosphere;
DOI:10.1021/jm4016284