230301-73-2

Basic information

• Product Name: tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate
• Synonyms: tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate;tert-butyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylate;Thieno[3,2-c]pyridine-5(4H)-carboxylic acid, 6,7-dihydro-, 1,1-diMethylethyl ester;tert-butyl 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-carboxylate;tert-butyl 6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylate;tert-Butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)
• CAS NO: 230301-73-2
• Molecular Formula: C12H17NO2S
• Molecular Weight: 239.33
• Product Categories: CHIRAL CHEMICALS;Heterocycle-Pyridine series
• Mol File: 230301-73-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 339.1 °C at 760 mmHg
• Flash Point: 158.9 °C
• Appearance: /
• Density: 1.173
• Vapor Pressure: 9.38E-05mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C(protect from light)
• PKA: -1.51±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate(230301-73-2)
• EPA Substance Registry System: tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate(230301-73-2)

Safety Data

• Hazardous Substances Data: 230301-73-2(Hazardous Substances Data)

Usage

General Description

Tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate is a chemical compound with a complex and specific structure. It belongs to the class of carboxylate esters and contains a thieno[3,2-c]pyridine core with a tert-butyl group attached. tert-butyl 6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate has potential applications in medicinal chemistry and drug discovery due to its unique structure and properties. Its synthesis and characterization are likely to be of interest to researchers in the field of organic synthesis and chemical biology.

InChI:InChI=1/C12H17NO2S/c1-12(2,3)15-11(14)13-6-4-10-9(8-13)5-7-16-10/h5,7H,4,6,8H2,1-3H3

Upstream product

• 28783-41-7 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride 
• 116118-99-1 4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-2-carboxylic acid hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 54903-50-3 4,5,6,7-tetrahydrothieno[3,2-c]pyridine 

Downstream Products

• 1078151-34-4 5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl-2-boronic acid 
• 1575610-00-2 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(pyridin-3-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-98-1 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(pyridin-4-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-95-8 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(2-cyanopyridin-5-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-93-6 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(pyrimidin-5-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-91-4 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(3-(trifluoromethyl)phenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-88-9 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(3-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-86-7 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(3-cyanophenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-84-5 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(3-fluorophenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-81-2 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(3-methylphenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-79-8 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-cyanophenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-77-6 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-methylphenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-74-3 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-73-2 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-(trifluoromethyl)phenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 

Relevant articles and documents

A method for preparing prasugrel intermediate

The invention provides a preparation method of a Prasugrel intermediate. The method comprises the following steps: performing an amino protection reaction by taking 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride as a raw material; and performing a halogenating reaction, an alkylation reaction, a sodium alkoxide deprotection reaction and an HCl gas acidifying reaction to obtain a target compound. The method is simple, advanced in process, small in the quantity of three wastes produced in a production process, low in environmental protection stress, high in yield, and suitable for industrial production.

PRMT5 INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof:wherein Y1 is of formula (?) or formula (y):Ring Y is a 5- to 6-membered heteroaryl ring; and V4, V5, Rx, x, y, and n are as defined herein. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

IMPROVED PROCESS FOR THE PREPARATION OF PRASUGREL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

The present invention relates to an improved process for the preparation of prasugrel compound of formula- 1 and its pharmaceutically acceptable salts thereof.