1,3-dimethyl-7(4'-methylphenyl)-8-methoxypyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,5,6(1H,3H,7H,10H)tetrone

Base Information

Chemical Name:1,3-dimethyl-7(4'-methylphenyl)-8-methoxypyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,5,6(1H,3H,7H,10H)tetrone
CAS No.:250332-72-0
Molecular Formula:C₁₉H₁₇N₅O₅
Molecular Weight:395.374
Hs Code.:

Synonyms:1,3-dimethyl-7(4'-methylphenyl)-8-methoxypyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,5,6(1H,3H,7H,10H)tetrone

Suppliers and Price of 1,3-dimethyl-7(4'-methylphenyl)-8-methoxypyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,5,6(1H,3H,7H,10H)tetrone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,3-dimethyl-7(4'-methylphenyl)-8-methoxypyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,5,6(1H,3H,7H,10H)tetrone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,3-dimethyl-7(4'-methylphenyl)-8-methoxypyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,5,6(1H,3H,7H,10H)tetrone

There total 5 articles about 1,3-dimethyl-7(4'-methylphenyl)-8-methoxypyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,5,6(1H,3H,7H,10H)tetrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.3%

: 622-58-2,374675-64-6
p-Tolylisocyanate

: 250332-68-4
methyl 1,3-dimethyl-2,4,5(1H,3H,8H)trioxo-7(triphenylphosphoranylideneamino)pyrido[2,3-d]pyrimidine-6-carboxylate

: 250332-72-0
1,3-dimethyl-7(4'-methylphenyl)-8-methoxypyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,5,6(1H,3H,7H,10H)tetrone

Guidance literature:: In toluene; for 16h; Heating;
DOI:10.1080/00397919908085913

Reference yield:

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 250332-72-0
1,3-dimethyl-7(4'-methylphenyl)-8-methoxypyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,5,6(1H,3H,7H,10H)tetrone

Guidance literature:: Multi-step reaction with 5 steps

1: 70.1 percent / pyridine / acetic anhydride / 3 h / 65 °C

2: 91.2 percent / NaOEt / ethanol / 1 h

3: 26 percent / NEt₃ / acetonitrile; hexachloroethane / 5 h / Heating

4: 83 percent / Et₃N / toluene / 1 h / Heating

5: 59.3 percent / toluene / 16 h / Heating

With pyridine; sodium ethanolate; triethylamine; In ethanol; hexachloroethane; acetic anhydride; toluene; acetonitrile; 1: Acylation / 2: Cyclization / 3: Substitution / 4: Carboxylation / 5: Cyclization;
DOI:10.1080/00397919908085913

Reference yield:

: 112735-05-4
3-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-3-oxopropanenitrile

: 250332-72-0
1,3-dimethyl-7(4'-methylphenyl)-8-methoxypyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,5,6(1H,3H,7H,10H)tetrone

Guidance literature:: Multi-step reaction with 4 steps

1: 91.2 percent / NaOEt / ethanol / 1 h

2: 26 percent / NEt₃ / acetonitrile; hexachloroethane / 5 h / Heating

3: 83 percent / Et₃N / toluene / 1 h / Heating

4: 59.3 percent / toluene / 16 h / Heating

With sodium ethanolate; triethylamine; In ethanol; hexachloroethane; toluene; acetonitrile; 1: Cyclization / 2: Substitution / 3: Carboxylation / 4: Cyclization;
DOI:10.1080/00397919908085913