1,3-dimethyl-7(4'-methylphenyl)-8-methoxy-5-oximino-10H-pyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,6(1H,3H,7H)trione

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Chemical Name:1,3-dimethyl-7(4'-methylphenyl)-8-methoxy-5-oximino-10H-pyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,6(1H,3H,7H)trione
CAS No.:250332-76-4
Molecular Formula:C₁₉H₁₈N₆O₅
Molecular Weight:410.389
Hs Code.:

Synonyms:1,3-dimethyl-7(4'-methylphenyl)-8-methoxy-5-oximino-10H-pyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,6(1H,3H,7H)trione

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Chemical Property of 1,3-dimethyl-7(4'-methylphenyl)-8-methoxy-5-oximino-10H-pyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,6(1H,3H,7H)trione

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Technology Process of 1,3-dimethyl-7(4'-methylphenyl)-8-methoxy-5-oximino-10H-pyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,6(1H,3H,7H)trione

There total 6 articles about 1,3-dimethyl-7(4'-methylphenyl)-8-methoxy-5-oximino-10H-pyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,6(1H,3H,7H)trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 250332-72-0
1,3-dimethyl-7(4'-methylphenyl)-8-methoxypyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,5,6(1H,3H,7H,10H)tetrone

: 250332-76-4
1,3-dimethyl-7(4'-methylphenyl)-8-methoxy-5-oximino-10H-pyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,6(1H,3H,7H)trione

Guidance literature:: With hydroxylamine hydrochloride; In methanol; for 4h; Heating;
DOI:10.1080/00397919908085913

Reference yield:

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 250332-76-4
1,3-dimethyl-7(4'-methylphenyl)-8-methoxy-5-oximino-10H-pyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,6(1H,3H,7H)trione

Guidance literature:: Multi-step reaction with 6 steps

1: 70.1 percent / pyridine / acetic anhydride / 3 h / 65 °C

2: 91.2 percent / NaOEt / ethanol / 1 h

3: 26 percent / NEt₃ / acetonitrile; hexachloroethane / 5 h / Heating

4: 83 percent / Et₃N / toluene / 1 h / Heating

5: 59.3 percent / toluene / 16 h / Heating

6: 86 percent / hydroxylamine hydrochloride / methanol / 4 h / Heating

With pyridine; hydroxylamine hydrochloride; sodium ethanolate; triethylamine; In methanol; ethanol; hexachloroethane; acetic anhydride; toluene; acetonitrile; 1: Acylation / 2: Cyclization / 3: Substitution / 4: Carboxylation / 5: Cyclization / 6: Substitution;
DOI:10.1080/00397919908085913

Reference yield:

: 112735-05-4
3-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-3-oxopropanenitrile

: 250332-76-4
1,3-dimethyl-7(4'-methylphenyl)-8-methoxy-5-oximino-10H-pyrimido[5',6':5,6]pyrido[2,3-d]pyrimidine-2,4,6(1H,3H,7H)trione

Guidance literature:: Multi-step reaction with 5 steps

1: 91.2 percent / NaOEt / ethanol / 1 h

2: 26 percent / NEt₃ / acetonitrile; hexachloroethane / 5 h / Heating

3: 83 percent / Et₃N / toluene / 1 h / Heating

4: 59.3 percent / toluene / 16 h / Heating

5: 86 percent / hydroxylamine hydrochloride / methanol / 4 h / Heating

With hydroxylamine hydrochloride; sodium ethanolate; triethylamine; In methanol; ethanol; hexachloroethane; toluene; acetonitrile; 1: Cyclization / 2: Substitution / 3: Carboxylation / 4: Cyclization / 5: Substitution;
DOI:10.1080/00397919908085913