2,6-dichloro-4-(3-(trifluoromethyl)phenyl)pyridine-3,5-dicarboxaldehyde

Base Information

Chemical Name:2,6-dichloro-4-(3-(trifluoromethyl)phenyl)pyridine-3,5-dicarboxaldehyde
CAS No.:129216-05-3
Molecular Formula:C₁₄H₆Cl₂F₃NO₂
Molecular Weight:348.108
Hs Code.:

Synonyms:2,6-dichloro-4-(3-(trifluoromethyl)phenyl)pyridine-3,5-dicarboxaldehyde

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Chemical Property of 2,6-dichloro-4-(3-(trifluoromethyl)phenyl)pyridine-3,5-dicarboxaldehyde

Chemical Property:

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Technology Process of 2,6-dichloro-4-(3-(trifluoromethyl)phenyl)pyridine-3,5-dicarboxaldehyde

There total 8 articles about 2,6-dichloro-4-(3-(trifluoromethyl)phenyl)pyridine-3,5-dicarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 129216-04-2
2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde

: 129216-05-3
2,6-dichloro-4-(3-(trifluoromethyl)phenyl)pyridine-3,5-dicarboxaldehyde

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetone; 0.25-0.5 h;
DOI:10.1021/jo00309a026

Reference yield:

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 129216-05-3
2,6-dichloro-4-(3-(trifluoromethyl)phenyl)pyridine-3,5-dicarboxaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / piperidine / benzene / 20 h / Heating

2: 82 percent / sodium ethoxide / ethanol / 3 h / Ambient temperature

3: 78 percent / conc HCl / 20 h / Heating

4: 63 percent / NH₃ / 0.5 h / 129 - 131 °C

5: 1.) POCl₃ / 1.) rt, 3 h 2.) 1,2-dichloroethane, rt, 15 h

6: sodium acetate / H₂O / Ambient temperature; 0.5-2 h

7: 88 percent / 0.5 N hydrochloric acid / tetrahydrofuran / Ambient temperature; 0.25-0.5 h

8: 94 percent / (NH₄)2Ce(NO₃)6 / H₂O; acetone / 0.25-0.5 h

With piperidine; hydrogenchloride; ammonium cerium(IV) nitrate; ammonia; sodium ethanolate; sodium acetate; trichlorophosphate; In tetrahydrofuran; ethanol; water; acetone; benzene;
DOI:10.1021/jo00309a026

Reference yield:

: 129215-95-8
4-(3-(trifluoromethyl)phenyl)glutarimide

: 129216-05-3
2,6-dichloro-4-(3-(trifluoromethyl)phenyl)pyridine-3,5-dicarboxaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) POCl₃ / 1.) rt, 3 h 2.) 1,2-dichloroethane, rt, 15 h

2: sodium acetate / H₂O / Ambient temperature; 0.5-2 h

3: 88 percent / 0.5 N hydrochloric acid / tetrahydrofuran / Ambient temperature; 0.25-0.5 h

4: 94 percent / (NH₄)2Ce(NO₃)6 / H₂O; acetone / 0.25-0.5 h

With hydrogenchloride; ammonium cerium(IV) nitrate; sodium acetate; trichlorophosphate; In tetrahydrofuran; water; acetone;
DOI:10.1021/jo00309a026