2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde

Base Information

Chemical Name:2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde
CAS No.:129216-04-2
Molecular Formula:C₁₄H₈Cl₂F₃NO₂
Molecular Weight:350.124
Hs Code.:

Synonyms:2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde

Suppliers and Price of 2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde

There total 7 articles about 2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 129215-99-2
2,6-Dichloro-5-[1-dimethylamino-meth-(Z)-ylidene]-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-pyridine-3-carbaldehyde

: 129216-04-2
2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; Ambient temperature; 0.25-0.5 h;
DOI:10.1021/jo00309a026

Reference yield:

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 129216-04-2
2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / piperidine / benzene / 20 h / Heating

2: 82 percent / sodium ethoxide / ethanol / 3 h / Ambient temperature

3: 78 percent / conc HCl / 20 h / Heating

4: 63 percent / NH₃ / 0.5 h / 129 - 131 °C

5: 1.) POCl₃ / 1.) rt, 3 h 2.) 1,2-dichloroethane, rt, 15 h

6: sodium acetate / H₂O / Ambient temperature; 0.5-2 h

7: 88 percent / 0.5 N hydrochloric acid / tetrahydrofuran / Ambient temperature; 0.25-0.5 h

With piperidine; hydrogenchloride; ammonia; sodium ethanolate; sodium acetate; trichlorophosphate; In tetrahydrofuran; ethanol; water; benzene;
DOI:10.1021/jo00309a026

Reference yield:

: 129215-95-8
4-(3-(trifluoromethyl)phenyl)glutarimide

: 129216-04-2
2,6-Dichloro-4-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) POCl₃ / 1.) rt, 3 h 2.) 1,2-dichloroethane, rt, 15 h

2: sodium acetate / H₂O / Ambient temperature; 0.5-2 h

3: 88 percent / 0.5 N hydrochloric acid / tetrahydrofuran / Ambient temperature; 0.25-0.5 h

With hydrogenchloride; sodium acetate; trichlorophosphate; In tetrahydrofuran; water;
DOI:10.1021/jo00309a026