L-MeVal-L-MeCys(Acm)-L-MeCys(Acm)-L-Pha-OAc

Base Information

Chemical Name:L-MeVal-L-MeCys(Acm)-L-MeCys(Acm)-L-Pha-OAc
CAS No.:851706-48-4
Molecular Formula:C₃₁H₅₀N₆O₇S₂
Molecular Weight:682.906
Hs Code.:

Synonyms:L-MeVal-L-MeCys(Acm)-L-MeCys(Acm)-L-Pha-OAc

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Chemical Property of L-MeVal-L-MeCys(Acm)-L-MeCys(Acm)-L-Pha-OAc

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Technology Process of L-MeVal-L-MeCys(Acm)-L-MeCys(Acm)-L-Pha-OAc

There total 8 articles about L-MeVal-L-MeCys(Acm)-L-MeCys(Acm)-L-Pha-OAc which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 851706-46-2
N-Fmoc-L-MeVal-L-MeCys(Acm)-L-MeCys(Acm)-L-Pha-OAc

: 851706-48-4
L-MeVal-L-MeCys(Acm)-L-MeCys(Acm)-L-Pha-OAc

Guidance literature:: With diethylamine; In dichloromethane; at 25 ℃; for 12h;
DOI:10.3987/COM-04-10287

Reference yield:

: 270587-80-9
N-BOC-N-Me-L-Cys(Acm)-OH

: 851706-48-4
L-MeVal-L-MeCys(Acm)-L-MeCys(Acm)-L-Pha-OAc

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxy-7-azabenzotriazole / dimethylformamide; CH₂Cl₂ / 12 h / 25 °C

2: 100 percent / TFA / CH₂Cl₂ / 3 h / 0 °C

3: 77 percent / bromotris(dimethylamino)phosphonium hexafluorophosphate; diisopropylethylamine / CH₂Cl₂ / 12 h / 25 °C

4: 81 percent / Et₂NH / CH₂Cl₂ / 12 h / 25 °C

With 1-hydroxy-7-aza-benzotriazole; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-04-10287

Reference yield:

: 1001852-00-1
H-NMe-Cys(Acm)-OH

: 851706-48-4
L-MeVal-L-MeCys(Acm)-L-MeCys(Acm)-L-Pha-OAc

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaOH

2: 58 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxy-7-azabenzotriazole / dimethylformamide; CH₂Cl₂ / 12 h / 25 °C

3: 100 percent / TFA / CH₂Cl₂ / 3 h / 0 °C

4: 77 percent / bromotris(dimethylamino)phosphonium hexafluorophosphate; diisopropylethylamine / CH₂Cl₂ / 12 h / 25 °C

5: 81 percent / Et₂NH / CH₂Cl₂ / 12 h / 25 °C

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-04-10287