[6-(3-amino-5-nitrophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetic acid

Base Information

Chemical Name:[6-(3-amino-5-nitrophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetic acid
CAS No.:618398-61-1
Molecular Formula:C₁₆H₁₈N₄O₅
Molecular Weight:346.343
Hs Code.:

Synonyms:[6-(3-amino-5-nitrophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetic acid

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Chemical Property of [6-(3-amino-5-nitrophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetic acid

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Technology Process of [6-(3-amino-5-nitrophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetic acid

There total 7 articles about [6-(3-amino-5-nitrophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374784-55-1
tert-butyl [6-{3-[(tert-butoxycarbonyl)amino]-5-nitrophenyl}-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetate

: 618398-61-1
[6-(3-amino-5-nitrophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 22h;
DOI:10.1021/jm0301686

Reference yield:

: 89466-18-2
6-bromo-2-methoxy-pyridin-3-ylamine

: 618398-61-1
[6-(3-amino-5-nitrophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) chloride / CH₂Cl₂ / 3 h / 20 °C

2: 5.7 g / sodium cyanoborohydride / CH₂Cl₂ / 14 h / 20 °C

3: 78 percent / boron tribromide / CH₂Cl₂ / 16 h / 20 °C

4: 66 percent / calcium hydride / tetrahydrofuran / 18 h / Heating

5: 39 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾; cesium carbonate / dioxane / 16 h / 80 °C

6: hydrochloric acid / H₂O; dioxane / 22 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; calcium hydride; boron tribromide; titanium tetrachloride; sodium cyanoborohydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 5: Suzuki coupling;
DOI:10.1016/S0040-4020(03)01239-0

Reference yield:

: 55304-80-8
2,6-dibromo-3-nitropyridine

: 618398-61-1
[6-(3-amino-5-nitrophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / acetic acid; iron / 0.25 h / 80 °C

2: 84 percent / dioxane / 48 h / Heating

3: titanium(IV) chloride / CH₂Cl₂ / 3 h / 20 °C

4: 5.7 g / sodium cyanoborohydride / CH₂Cl₂ / 14 h / 20 °C

5: 78 percent / boron tribromide / CH₂Cl₂ / 16 h / 20 °C

6: 66 percent / calcium hydride / tetrahydrofuran / 18 h / Heating

7: 39 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾; cesium carbonate / dioxane / 16 h / 80 °C

8: hydrochloric acid / H₂O; dioxane / 22 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; calcium hydride; boron tribromide; titanium tetrachloride; iron; sodium cyanoborohydride; caesium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 7: Suzuki coupling;
DOI:10.1016/S0040-4020(03)01239-0