2,6-Dibromo-3-nitropyridine

Base Information

• Chemical Name: 2,6-Dibromo-3-nitropyridine
• CAS No.: 55304-80-8
• Molecular Formula: C5H2Br2N2O2
• Molecular Weight: 281.891
• Hs Code.: 29333990
• DSSTox Substance ID: DTXSID60339262
• Nikkaji Number: J392.189A
• Wikidata: Q72464697
• Mol file: 55304-80-8.mol

Synonyms:2,6-Dibromo-3-nitropyridine;55304-80-8;2,6-Dibromo-3-nitro-pyridine;PYRIDINE, 2,6-DIBROMO-3-NITRO-;MFCD00233995;SCHEMBL40986;2,6-Dibromo-5-nitropyridine;2,6-Dibromo-3-nitro-pyridin;2,6-dibromo-3-nitro pyridine;DTXSID60339262;BBL101186;STL554982;AKOS005257115;CS-W000354;PB30628;AC-28006;AS-11334;SY004461;A8012;AM20061318;FT-0602751;EN300-86216;W-203086

Chemical Property of 2,6-Dibromo-3-nitropyridine

Chemical Property:

• Melting Point: 78 °C
• Boiling Point: 295.8 °C at 760 mmHg
• PKA: -7.68±0.10(Predicted)
• Flash Point: 132.7 °C
• PSA: 58.71000
• Density: 2.221 g/cm³
• LogP: 3.03800
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 281.84625
• Heavy Atom Count: 11
• Complexity: 161

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dibromo-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1[N+](=O)[O-])Br)Br
• Uses: 2,6-Dibromo-3-nitropyridine is a useful reagent for organic synthesis and other chemical processes. It is used as a reagent in the synthesis of amino(carbamoylmethyl) pyridones as factor VIIa inhibitors and anticoagulants.

Technology Process of 2,6-Dibromo-3-nitropyridine

There total 3 articles about 2,6-Dibromo-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) → 2,6-dibromo-3-nitropyridine (55304-80-8)

Guidance literature:

With hydrogen bromide; acetic acid; at 80 ℃; for 3h;

Reference yield: 47.9%

2,6-Dibromopyridine (626-05-1) → 2,6-dibromo-3-nitropyridine (55304-80-8)

Guidance literature:

With nitronium tetrafluoborate; In acetonitrile; for 20h; Heating;

DOI:10.1021/jo00009a015

Reference yield:

→ 2,6-dibromo-3-nitropyridine (55304-80-8)

Guidance literature:

22, HBr;

DOI:10.1002/hlca.19760590125

upstream raw materials:

2,6-Dibromopyridine

2,6-dicholoro-3-nitropyridine

Downstream raw materials:

benzyl (1E)-amino{4-[({[6-(3-amino-5-nitrophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetyl}amino)methyl]phenyl}methylidenecarbamate

benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate

C₉H₈Br₂N₂

5-bromo-N-(4-methoxyphenyl)-3-(3-(piperidin-1-yl)propyl)-3H-imidazo[4,5-b]pyridin-2-amine