4-ethynylbenzyl((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)carbamate

Base Information

Chemical Name:4-ethynylbenzyl((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)carbamate
CAS No.:1354894-17-9
Molecular Formula:C₃₆H₃₄N₂O₅S
Molecular Weight:606.742
Hs Code.:

Synonyms:4-ethynylbenzyl((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)carbamate

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Chemical Property of 4-ethynylbenzyl((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)carbamate

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Technology Process of 4-ethynylbenzyl((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)carbamate

There total 12 articles about 4-ethynylbenzyl((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1354894-23-7
(S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoic acid

: (S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-aminium 2,2,2-trifluoroacetate

: 1354894-17-9
4-ethynylbenzyl((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)carbamate

Guidance literature:: (S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

(S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-aminium 2,2,2-trifluoroacetate; In N,N-dimethyl-formamide; at 20 ℃; for 21h; Inert atmosphere;
DOI:10.1039/c1cc16178d

Reference yield:

: 56069-39-7
diethyl phenylsulfonylmethylphosphonate

: 1354894-17-9
4-ethynylbenzyl((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: dichloromethane / 2 h / 0 °C / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

3.2: 21 h / 20 °C / Inert atmosphere

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c1cc16178d

Reference yield:

: 38066-16-9
diethyl [(phenylthio)methyl]phosphonate

: 1354894-17-9
4-ethynylbenzyl((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

3.1: dichloromethane / 2 h / 0 °C / Inert atmosphere

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

4.2: 21 h / 20 °C / Inert atmosphere

With sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c1cc16178d