(S)-methyl 2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoate

Base Information

Chemical Name:(S)-methyl 2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoate
CAS No.:1354894-22-6
Molecular Formula:C₂₀H₁₉NO₄
Molecular Weight:337.375
Hs Code.:

Synonyms:(S)-methyl 2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoate

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Chemical Property of (S)-methyl 2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoate

Chemical Property:

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Technology Process of (S)-methyl 2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoate

There total 5 articles about (S)-methyl 2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 10602-04-7
(4-ethynylphenyl)methanol

: 40203-94-9
methyl (S)-2-isocyanato-3-phenylpropanoate

: 1354894-22-6
(S)-methyl 2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoate

Guidance literature:: In toluene; at 100 ℃; for 6h; Inert atmosphere;
DOI:10.1039/c1cc16178d

Reference yield:

: 4-ethynylbenzyl carbonochloridate

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 1354894-22-6
(S)-methyl 2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoate

Guidance literature:: With sodium carbonate; In toluene; at 10 ℃; for 3h;
DOI:10.1016/j.bioorg.2019.02.032

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 1354894-22-6
(S)-methyl 2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane; water / 0.25 h / 0 °C / Inert atmosphere

2: toluene / 6 h / 100 °C / Inert atmosphere

With sodium hydrogencarbonate; In dichloromethane; water; toluene;
DOI:10.1039/c1cc16178d