2-(Benzyloxy)-3-(3-[6-(benzyloxy)pyridin-2-yl]-1-{[tert-butyl(dimethyl)silyl]oxy}prop-2-ynyl)-6,7-dihydro-5H-cyclopenta[b]pyridine

Base Information

Chemical Name:2-(Benzyloxy)-3-(3-[6-(benzyloxy)pyridin-2-yl]-1-{[tert-butyl(dimethyl)silyl]oxy}prop-2-ynyl)-6,7-dihydro-5H-cyclopenta[b]pyridine
CAS No.:234752-98-8
Molecular Formula:C₃₆H₄₀N₂O₃Si
Molecular Weight:576.811
Hs Code.:

Synonyms:2-(Benzyloxy)-3-(3-[6-(benzyloxy)pyridin-2-yl]-1-{[tert-butyl(dimethyl)silyl]oxy}prop-2-ynyl)-6,7-dihydro-5H-cyclopenta[b]pyridine

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Chemical Property of 2-(Benzyloxy)-3-(3-[6-(benzyloxy)pyridin-2-yl]-1-{[tert-butyl(dimethyl)silyl]oxy}prop-2-ynyl)-6,7-dihydro-5H-cyclopenta[b]pyridine

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Technology Process of 2-(Benzyloxy)-3-(3-[6-(benzyloxy)pyridin-2-yl]-1-{[tert-butyl(dimethyl)silyl]oxy}prop-2-ynyl)-6,7-dihydro-5H-cyclopenta[b]pyridine

There total 7 articles about 2-(Benzyloxy)-3-(3-[6-(benzyloxy)pyridin-2-yl]-1-{[tert-butyl(dimethyl)silyl]oxy}prop-2-ynyl)-6,7-dihydro-5H-cyclopenta[b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 201274-51-3
1-[2-(Benzyloxy)-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl]-3-[6-(benzyloxy)pyridin-2-yl]prop-2-yn-1-ol

: 234752-98-8
2-(Benzyloxy)-3-(3-[6-(benzyloxy)pyridin-2-yl]-1-{[tert-butyl(dimethyl)silyl]oxy}prop-2-ynyl)-6,7-dihydro-5H-cyclopenta[b]pyridine

Guidance literature:: With 1H-imidazole; In acetonitrile; at 20 ℃; for 18h;
DOI:10.1055/s-2001-15066

Reference yield:

: 108106-97-4
2-oxo-2,5,6,7-tetrahydro-3-cyano-1H-cyclopenta[b]pyridine-3-carbonitrile

: 234752-98-8
2-(Benzyloxy)-3-(3-[6-(benzyloxy)pyridin-2-yl]-1-{[tert-butyl(dimethyl)silyl]oxy}prop-2-ynyl)-6,7-dihydro-5H-cyclopenta[b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / Ag₂CO₃ / toluene / 96 h

2.1: 92 percent / DIBAL / CH₂Cl₂ / 1 h / -78 °C

3.1: EtMgBr / tetrahydrofuran / 0.5 h

3.2: 86 percent / tetrahydrofuran / 0.08 h

4.1: 87 percent / imidazole / acetonitrile / 18 h / 20 °C

With 1H-imidazole; ethylmagnesium bromide; diisobutylaluminium hydride; silver carbonate; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1055/s-2001-15066

Reference yield:

: 201274-49-9
2-(Benzyloxy)-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbaldehyde

: 234752-98-8
2-(Benzyloxy)-3-(3-[6-(benzyloxy)pyridin-2-yl]-1-{[tert-butyl(dimethyl)silyl]oxy}prop-2-ynyl)-6,7-dihydro-5H-cyclopenta[b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: EtMgBr / tetrahydrofuran / 0.5 h

1.2: 86 percent / tetrahydrofuran / 0.08 h

2.1: 87 percent / imidazole / acetonitrile / 18 h / 20 °C

With 1H-imidazole; ethylmagnesium bromide; In tetrahydrofuran; acetonitrile;
DOI:10.1055/s-2001-15066