(-)-(2R,4R,1'S)-4-(2-O-benzoyl-1-hydroxyethyl)-2-(hydroxymethyl)dioxolane

Base Information

Chemical Name:(-)-(2R,4R,1'S)-4-(2-O-benzoyl-1-hydroxyethyl)-2-(hydroxymethyl)dioxolane
CAS No.:136884-11-2
Molecular Formula:C₁₃H₁₆O₆
Molecular Weight:268.266
Hs Code.:

Synonyms:(-)-(2R,4R,1'S)-4-(2-O-benzoyl-1-hydroxyethyl)-2-(hydroxymethyl)dioxolane

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Chemical Property of (-)-(2R,4R,1'S)-4-(2-O-benzoyl-1-hydroxyethyl)-2-(hydroxymethyl)dioxolane

Chemical Property:

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Technology Process of (-)-(2R,4R,1'S)-4-(2-O-benzoyl-1-hydroxyethyl)-2-(hydroxymethyl)dioxolane

There total 4 articles about (-)-(2R,4R,1'S)-4-(2-O-benzoyl-1-hydroxyethyl)-2-(hydroxymethyl)dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: Benzoic acid (S)-2-hydroxy-1-((2R,4R)-2-hydroxymethyl-[1,3]dioxolan-4-yl)-ethyl ester

: 136884-11-2
(-)-(2R,4R,1'S)-4-(2-O-benzoyl-1-hydroxyethyl)-2-(hydroxymethyl)dioxolane

Guidance literature:: DOI:10.1016/S0040-4039(00)79377-4

Reference yield:

: 131940-20-0
(-)-1,6-anhydro-4-O-benzoyl-2,3-isopropylidene-β-D-mannopyranose

: 136884-11-2
(-)-(2R,4R,1'S)-4-(2-O-benzoyl-1-hydroxyethyl)-2-(hydroxymethyl)dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: conc. H₂SO₄ / dioxane; H₂O / 15 h / 70 - 80 °C

2: 1.) NaIO₄, 2.) NaBH₄ / 1.) water, EtOH, RT, 1 h, 2.) water, EtOH, 10 min

With sodium tetrahydroborate; sodium periodate; sulfuric acid; In 1,4-dioxane; water;
DOI:10.1021/jm00089a007

Reference yield:

: 98-88-4
benzoyl chloride

: 136884-11-2
(-)-(2R,4R,1'S)-4-(2-O-benzoyl-1-hydroxyethyl)-2-(hydroxymethyl)dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: 98.2 percent / pyridine / 0.75 h / 0 °C

2: conc. H₂SO₄ / dioxane; H₂O / 15 h / 70 - 80 °C

3: 1.) NaIO₄, 2.) NaBH₄ / 1.) water, EtOH, RT, 1 h, 2.) water, EtOH, 10 min

With pyridine; sodium tetrahydroborate; sodium periodate; sulfuric acid; In 1,4-dioxane; water;
DOI:10.1021/jm00089a007