(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-butyl}-phenoxy)-acetic acid tert-butyl ester

Base Information

Chemical Name:(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-butyl}-phenoxy)-acetic acid tert-butyl ester
CAS No.:587880-07-7
Molecular Formula:C₂₂H₃₀ClN₇O₄
Molecular Weight:491.978
Hs Code.:

(4-{4-[<i>N</i>'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-butyl}-phenoxy)-acetic acid <i>tert</i>-butyl ester

Synonyms:(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-butyl}-phenoxy)-acetic acid tert-butyl ester

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Chemical Property of (4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-butyl}-phenoxy)-acetic acid tert-butyl ester

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Technology Process of (4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-butyl}-phenoxy)-acetic acid tert-butyl ester

There total 10 articles about (4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-butyl}-phenoxy)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 905293-39-2
[4-(4-amino-butyl)-phenoxy]-acetic acid tert-butyl ester

: 1-(3,5-diamino-6-chloropyrazine-2-carbonyl)-2-methylisothiourea hydroiodide

: 587880-07-7
(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-butyl}-phenoxy)-acetic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 65 ℃;
DOI:10.1021/jm051134w

Reference yield:

: 583825-27-8
1-(4-azidobutyl)-4-methoxybezene

: 587880-07-7
(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-butyl}-phenoxy)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 94 percent / Ph₃P; H₂O / tetrahydrofuran / 20 °C

2.1: 90 percent / aq. HBr / 3 h / Heating

3.1: 62 percent / sodium bicarbonate / dioxane; H₂O / -2 - 20 °C

4.1: NaH / tetrahydrofuran / 0 °C

4.2: 99 percent / tetrabutylammonium iodide / tetrahydrofuran / 20 - 50 °C

5.1: 93 percent / H₂ / Pd/C / 20 °C / 760 Torr

6.1: 16 percent / diisopropylethylamine / 65 °C

With water; hydrogen bromide; hydrogen; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm051134w

Reference yield:

: 587880-25-9
4-(4-hydroxyphenyl)butylcarbamic acid benzyl ester

: 587880-07-7
(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-butyl}-phenoxy)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0 °C

1.2: 99 percent / tetrabutylammonium iodide / tetrahydrofuran / 20 - 50 °C

2.1: 93 percent / H₂ / Pd/C / 20 °C / 760 Torr

3.1: 16 percent / diisopropylethylamine / 65 °C

With hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jm051134w