(E)-1-(1,4-Dioxa-spiro[4.5]dec-7-yl)-7-[4-(trityl-amino)-phenyl]-hept-1-en-3-one

Base Information

Chemical Name:(E)-1-(1,4-Dioxa-spiro[4.5]dec-7-yl)-7-[4-(trityl-amino)-phenyl]-hept-1-en-3-one
CAS No.:279669-89-5
Molecular Formula:C₄₀H₄₃NO₃
Molecular Weight:585.786
Hs Code.:

Synonyms:(E)-1-(1,4-Dioxa-spiro[4.5]dec-7-yl)-7-[4-(trityl-amino)-phenyl]-hept-1-en-3-one

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Chemical Property of (E)-1-(1,4-Dioxa-spiro[4.5]dec-7-yl)-7-[4-(trityl-amino)-phenyl]-hept-1-en-3-one

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Technology Process of (E)-1-(1,4-Dioxa-spiro[4.5]dec-7-yl)-7-[4-(trityl-amino)-phenyl]-hept-1-en-3-one

There total 6 articles about (E)-1-(1,4-Dioxa-spiro[4.5]dec-7-yl)-7-[4-(trityl-amino)-phenyl]-hept-1-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 65005-14-3
1,4-dioxa-spiro[4.5]decane-7-carbaldehyde

: 279669-88-4
diethyl 2-oxo-6-(4-tritylamino)phenylhexylphosphonate

: 279669-89-5
(E)-1-(1,4-Dioxa-spiro[4.5]dec-7-yl)-7-[4-(trityl-amino)-phenyl]-hept-1-en-3-one

Guidance literature:: With sodium hydride; at -40 ℃;
DOI:10.1016/S0960-894X(00)00103-7

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 279669-89-5
(E)-1-(1,4-Dioxa-spiro[4.5]dec-7-yl)-7-[4-(trityl-amino)-phenyl]-hept-1-en-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / t-BuOK / tetrahydrofuran

2: 98 percent / H₂SO₄

3: 100 percent / H₂ / 5 percent Pd/C / 2844.31 Torr

4: 90 percent / pyridine

5: 85 percent / n-BuLi / tetrahydrofuran; toluene

6: 75 percent / NaH / -40 °C

With pyridine; n-butyllithium; sulfuric acid; potassium tert-butylate; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; toluene; 1: Wittig reaction / 2: Esterification / 3: Catalytic hydrogenation / 4: tritylation / 5: Condensation / 6: Wadsworth-Horner-Emmons reaction;
DOI:10.1016/S0960-894X(00)00103-7

Reference yield:

: (E)-5-(4-nitrophenyl)pent-4-enoic acid

: 279669-89-5
(E)-1-(1,4-Dioxa-spiro[4.5]dec-7-yl)-7-[4-(trityl-amino)-phenyl]-hept-1-en-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / H₂SO₄

2: 100 percent / H₂ / 5 percent Pd/C / 2844.31 Torr

3: 90 percent / pyridine

4: 85 percent / n-BuLi / tetrahydrofuran; toluene

5: 75 percent / NaH / -40 °C

With pyridine; n-butyllithium; sulfuric acid; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; toluene; 1: Esterification / 2: Catalytic hydrogenation / 3: tritylation / 4: Condensation / 5: Wadsworth-Horner-Emmons reaction;
DOI:10.1016/S0960-894X(00)00103-7