4-(4-benzyloxy-3-methoxyphenyl)-3-(pyrrol-1-yl)thien-2-ylpyrrolidine carboxamide

Base Information

Chemical Name:4-(4-benzyloxy-3-methoxyphenyl)-3-(pyrrol-1-yl)thien-2-ylpyrrolidine carboxamide
CAS No.:679425-66-2
Molecular Formula:C₂₇H₂₆N₂O₃S
Molecular Weight:458.581
Hs Code.:

Synonyms:4-(4-benzyloxy-3-methoxyphenyl)-3-(pyrrol-1-yl)thien-2-ylpyrrolidine carboxamide

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Chemical Property of 4-(4-benzyloxy-3-methoxyphenyl)-3-(pyrrol-1-yl)thien-2-ylpyrrolidine carboxamide

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Technology Process of 4-(4-benzyloxy-3-methoxyphenyl)-3-(pyrrol-1-yl)thien-2-ylpyrrolidine carboxamide

There total 11 articles about 4-(4-benzyloxy-3-methoxyphenyl)-3-(pyrrol-1-yl)thien-2-ylpyrrolidine carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 123-75-1
pyrrolidine

: 679425-93-5
methyl 4-(4-benzyloxy-3-methoxyphenyl)-3-(pyrrol-1-yl)-2-thiophene carboxylate

: 679425-66-2
4-(4-benzyloxy-3-methoxyphenyl)-3-(pyrrol-1-yl)thien-2-ylpyrrolidine carboxamide

Guidance literature:: for 2.5h; Heating;
DOI:10.1021/jm030961z

Reference yield:

: 1700-29-4
2-(4-(benzyloxy)-3-methoxyphenyl)acetonitrile

: 679425-66-2
4-(4-benzyloxy-3-methoxyphenyl)-3-(pyrrol-1-yl)thien-2-ylpyrrolidine carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 92 percent / NaOMe / methanol / 2 h / Heating

2.1: 52 percent / dimethylformamide / 2 h / 70 °C

3.1: 64 percent / NaOMe / methanol / 2 h / 60 °C

4.1: 4-chloropyridine hydrochloride / dioxane / 0.25 h / Heating

4.2: 76 percent / 4-chloropyridine hydrochloride / dioxane / 3 h / Heating

5.1: 82 percent / 2.5 h / Heating

With sodium methylate; 4-chlorpyridine hydrochloride; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030961z

Reference yield:

: 679425-83-3
2-cyano-2-(4-benzyloxy-3-methoxyphenyl)vinylbenzene sulfonate

: 679425-66-2
4-(4-benzyloxy-3-methoxyphenyl)-3-(pyrrol-1-yl)thien-2-ylpyrrolidine carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 64 percent / NaOMe / methanol / 2 h / 60 °C

2.1: 4-chloropyridine hydrochloride / dioxane / 0.25 h / Heating

2.2: 76 percent / 4-chloropyridine hydrochloride / dioxane / 3 h / Heating

3.1: 82 percent / 2.5 h / Heating

With sodium methylate; 4-chlorpyridine hydrochloride; In 1,4-dioxane; methanol;
DOI:10.1021/jm030961z