(5R)-ethyl hydrogen 5-benzyl-5-benzyloxycarbonylamino-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

Base Information

Chemical Name:(5R)-ethyl hydrogen 5-benzyl-5-benzyloxycarbonylamino-3-oxo-2-(triphenylphosphoranylidene)hexanedioate
CAS No.:169787-91-1
Molecular Formula:C₄₁H₃₈NO₇P
Molecular Weight:687.729
Hs Code.:

Synonyms:(5R)-ethyl hydrogen 5-benzyl-5-benzyloxycarbonylamino-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

Suppliers and Price of (5R)-ethyl hydrogen 5-benzyl-5-benzyloxycarbonylamino-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R)-ethyl hydrogen 5-benzyl-5-benzyloxycarbonylamino-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

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Technology Process of (5R)-ethyl hydrogen 5-benzyl-5-benzyloxycarbonylamino-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

There total 6 articles about (5R)-ethyl hydrogen 5-benzyl-5-benzyloxycarbonylamino-3-oxo-2-(triphenylphosphoranylidene)hexanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 169873-64-7
(2'S,4'R)-(-)-4-(4'-benzyl-3'-benzyloxycarbonyl-5'-oxo-2'-phenyloxazolidin-4'-yl)-3-oxo-2-(triphenylphosphoranylidene)butanoate

: 169787-91-1
(5R)-ethyl hydrogen 5-benzyl-5-benzyloxycarbonylamino-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; for 4h; Heating;
DOI:10.1021/jo00053a006

Reference yield:

: 95260-60-9
(2S,4S)-benzyl 4-benzyl-5-oxo-2-phenyloxazolidine-3-carboxylate

: 169787-91-1
(5R)-ethyl hydrogen 5-benzyl-5-benzyloxycarbonylamino-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) LiHMDS / 1) THF, -78 deg C

2: 95 percent / LiOH / tetrahydrofuran; methanol / 4 h / Heating

With lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.1021/jo00053a006

Reference yield:

: 20341-92-8
4-Bromo-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-butyric acid ethyl ester

: 169787-91-1
(5R)-ethyl hydrogen 5-benzyl-5-benzyloxycarbonylamino-3-oxo-2-(triphenylphosphoranylidene)hexanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) LiHMDS / 1) THF, -78 deg C

2: 95 percent / LiOH / tetrahydrofuran; methanol / 4 h / Heating

With lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.1021/jo00053a006