Technology Process of (2R,3R,4S,6R,8E)-3-benzyloxy-1,2-isopropylidendioxy-4,6,8-trimethyl-8-decene
There total 12 articles about (2R,3R,4S,6R,8E)-3-benzyloxy-1,2-isopropylidendioxy-4,6,8-trimethyl-8-decene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-2-bromobut-2-ene;
With
lithium;
In
diethyl ether;
at 20 ℃;
for 2h;
(2R,3R,4S,6R)-3-benzyloxy-7-iodo-1,2-isopropylidendioxy-4,6-dimethylheptane;
In
diethyl ether;
at 0 - 20 ℃;
DOI:10.1016/j.tet.2004.12.013
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 80 percent / AD-mix-β; methanesulfonamide / 2-methyl-propan-2-ol; H2O / 45 h / 20 °C
2.1: 83 percent / p-toluenesulfonic acid monohydrate / CH2Cl2 / 1 h / 20 °C
3.1: 83 percent / lithium aluminium hydride / tetrahydrofuran / 0.5 h / 0 °C
4.1: borane-dimethylsulfide complex / CH2Cl2 / 1 h / 0 - 20 °C
4.2: 70 percent / BF3*Et2O / CH2Cl2 / 0.17 h / 0 °C
5.1: 91 percent / p-toluenesulfonic acid monohydrate / CH2Cl2 / 1 h / 20 °C
6.1: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
7.1: 95 percent / iodine; triphenylphosphine; imidazole / benzene / 2 h / 20 °C
8.1: lithium / diethyl ether / 2 h / 20 °C
8.2: 62 percent / diethyl ether / 0 - 20 °C
With
1H-imidazole; lithium aluminium tetrahydride; methanesulfonamide; dimethylsulfide borane complex; AD-mix-β; tetrabutyl ammonium fluoride; iodine; lithium; toluene-4-sulfonic acid; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1016/j.tet.2004.12.013
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 95 percent / iodine; triphenylphosphine; imidazole / benzene / 2 h / 20 °C
2.1: lithium / diethyl ether / 2 h / 20 °C
2.2: 62 percent / diethyl ether / 0 - 20 °C
With
1H-imidazole; iodine; lithium; triphenylphosphine;
In
diethyl ether; benzene;
DOI:10.1016/j.tet.2004.12.013
