2-[(3',4'-difluorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl benzoate

Base Information

Chemical Name:2-[(3',4'-difluorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl benzoate
CAS No.:1369963-27-8
Molecular Formula:C₃₁H₂₆F₂N₄O₅S
Molecular Weight:604.634
Hs Code.:

Synonyms:2-[(3',4'-difluorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl benzoate

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Chemical Property of 2-[(3',4'-difluorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl benzoate

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Technology Process of 2-[(3',4'-difluorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl benzoate

There total 7 articles about 2-[(3',4'-difluorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369963-26-7
2-[(4-bromophenyl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl benzoate

: 168267-41-2
(3,4-difluorophenyl)boronic acid

: 1369963-27-8
2-[(3',4'-difluorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl benzoate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 110 ℃; for 3h;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1369963-27-8
2-[(3',4'-difluorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 1 h

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

With pyridine; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4284-50-8
N-(4-bromophenyl)methanesulfonamide

: 1369963-27-8
2-[(3',4'-difluorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

With di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;