10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one

Base Information

Chemical Name:10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one
CAS No.:1296216-56-2
Molecular Formula:C₁₉H₁₆F₃NO
Molecular Weight:331.337
Hs Code.:

Synonyms:10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one

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Chemical Property of 10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one

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Technology Process of 10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one

There total 6 articles about 10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1296216-53-9
10-(4-(trifluoromethyl)phenyl)-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one

: 1296216-56-2
10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one

Guidance literature:: With platinum(IV) oxide; hydrogen; In ethanol; for 2h; under 760.051 Torr;
DOI:10.1021/ol200709h

Reference yield:

: 1296216-51-7
10-chloro-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one

: 1296216-56-2
10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

2: platinum(IV) oxide; hydrogen / ethanol / 2 h / 760.05 Torr

With platinum(IV) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; hydrogen; caesium carbonate; In 1,4-dioxane; ethanol;
DOI:10.1021/ol200709h

Reference yield:

: 1296216-47-1
allyl-[1-(2-bromo-6-chloro-phenyl)-but-3-enyl]-carbamic acid benzyl ester

: 1296216-56-2
10-(4-trifluoromethyl-phenyl)-1,3,4,10b-tetrahydro-2H-pyrido[2,1-a]isoindol-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 14.5 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -100 - -78 °C / Inert atmosphere

2.2: -78 °C / Saturated solution

3.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

4.1: platinum(IV) oxide; hydrogen / ethanol / 2 h / 760.05 Torr

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; platinum(IV) oxide; n-butyllithium; bis(tri-t-butylphosphine)palladium⁽⁰⁾; hydrogen; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane;
DOI:10.1021/ol200709h