10-(4-(trifluoromethyl)phenyl)-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one

Base Information

Chemical Name:10-(4-(trifluoromethyl)phenyl)-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one
CAS No.:1296216-53-9
Molecular Formula:C₁₉H₁₄F₃NO
Molecular Weight:329.321
Hs Code.:

Synonyms:10-(4-(trifluoromethyl)phenyl)-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one

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Chemical Property of 10-(4-(trifluoromethyl)phenyl)-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one

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Technology Process of 10-(4-(trifluoromethyl)phenyl)-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one

There total 5 articles about 10-(4-(trifluoromethyl)phenyl)-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1296216-51-7
10-chloro-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1296216-53-9
10-(4-(trifluoromethyl)phenyl)-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; at 100 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol200709h

Reference yield:

: 1296216-47-1
allyl-[1-(2-bromo-6-chloro-phenyl)-but-3-enyl]-carbamic acid benzyl ester

: 1296216-53-9
10-(4-(trifluoromethyl)phenyl)-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 14.5 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -100 - -78 °C / Inert atmosphere

2.2: -78 °C / Saturated solution

3.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; n-butyllithium; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1021/ol200709h

Reference yield:

: 1296216-50-6
benzyl 2-(2-bromo-6-chlorophenyl)-1,2,3,6-tetrahydropyridine-1(2H)-carboxylate

: 1296216-53-9
10-(4-(trifluoromethyl)phenyl)-1,10b-dihydropyrido[2,1-a]isoindol-6(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -100 - -78 °C / Inert atmosphere

1.2: -78 °C / Saturated solution

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

With n-butyllithium; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; hexane;
DOI:10.1021/ol200709h