Chemical Property of Dihydrolycorine
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:247 °C
- Refractive Index:1.701
- Boiling Point:460.5 °C at 760 mmHg
- PKA:14.13±0.40(Predicted)
- Flash Point:232.3 °C
- PSA：62.16000
- Density:1.48 g/cm3
- LogP:0.76640
- XLogP3:0.7
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:0
- Exact Mass:289.13140809
- Heavy Atom Count:21
- Complexity:433
- Purity/Quality:
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≥98% *data from raw suppliers
Dihydrolycorine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CN2CC3=CC4=C(C=C3C5C2C1CC(C5O)O)OCO4
- Isomeric SMILES:C1CN2CC3=CC4=C(C=C3[C@H]5[C@H]2[C@H]1C[C@@H]([C@H]5O)O)OCO4
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Uses
Dihydrolycorine is a derivative of Lycorine, the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli. Dihydrolycorine is a derivative of Lycorine (L487550), the main phenanthridine Amaryllidaceae alkaloid which exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli.
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Description
Dihydrolycorine is a derivative of the alkaloid lycorine that has antihypertensive and neuroprotective activities. It inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively. Dihydrolycorine reduces mean arterial pressure (MAP) in anesthetized and conscious normotensive rats when administered at a dose of 80 mg/kg. It also reduces electrically or phenylephrine-induced hypertension in pithed rats. Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion.
