[18F]-3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide

Base Information

• Chemical Name: [18F]-3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide
• CAS No.: 1443039-75-5
• Molecular Formula: C₂₀H₂₉FN₄O₃Si
• Molecular Weight: 419.561
• Mol file: 1443039-75-5.mol

Synonyms:[18F]-3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide

Chemical Property of [18F]-3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [18F]-3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide

There total 12 articles about [18F]-3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-(ditert-butylsilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide (1443039-74-4) → [18F]-3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide (1443039-75-5)

Guidance literature:

With 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; acetic acid; In dimethyl sulfoxide; acetonitrile; at 100 ℃; for 0.25h;

DOI:10.1016/j.bmc.2013.04.029

Reference yield: 64.0%

3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide (1443039-71-1) → [18F]-3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide (1443039-75-5)

Guidance literature:

With 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; acetic acid; In acetonitrile; at 100 ℃; for 0.25h;

DOI:10.1016/j.bmc.2013.04.029

Reference yield:

[(3-bromobenzyl)oxy](tert-butyl)dimethylsilane (103978-12-7) → [18F]-3-(ditert-butylfluorosilyl)-N-(2-(2-nitro-1H-imidazol-1-yl)ethyl)benzamide (1443039-75-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane; Cyclopentane / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: hydrogenchloride / methanol; water / 20 °C

3.1: Jones reagent / acetone / 0.5 h / 0 °C

4.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 24 h / 20 °C

5.1: acetic acid; 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride / acetonitrile; dimethyl sulfoxide / 0.25 h / 100 °C

With hydrogenchloride; Jones reagent; 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; tert.-butyl lithium; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; Cyclopentane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile; pentane;

DOI:10.1016/j.bmc.2013.04.029

upstream raw materials:

ditert-butyl(3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)fluorosilane

tert-butyl((3-(ditert-butylsilyl)benzyl)oxy)dimethylsilane

3-(ditert-butylfluorosilyl)benzyl alcohol

3-(ditert-butylsilyl)benzyl alcohol