N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide

Base Information

Chemical Name:N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide
CAS No.:1394165-15-1
Molecular Formula:C₃₉H₃₃F₄N₅O₅
Molecular Weight:727.715
Hs Code.:

N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide

Synonyms:N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide

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Chemical Property of N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide

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Technology Process of N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide

There total 18 articles about N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394166-11-0
3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)aniline

: 1394166-15-4
4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carbonyl chloride

: 1394165-15-1
N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 10h; Cooling with ice;
DOI:10.1016/j.bmc.2013.04.013

Reference yield:

: 1160707-44-7
1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

: 1394165-15-1
N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: toluene / 10 h / 110 °C

2: acetic acid / 2 h / 60 - 80 °C

3: acetonitrile / 10 h / 85 °C

4: trichlorophosphate / acetonitrile / 6 h / 85 °C

5: chlorobenzene / 30 h / 140 °C

6: ammonium chloride; iron / ethanol; water / 5 h / Reflux

7: triethylamine / dichloromethane / 10 h / 20 °C / Cooling with ice

With iron; ammonium chloride; triethylamine; trichlorophosphate; In ethanol; dichloromethane; water; acetic acid; chlorobenzene; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.04.013

Reference yield:

: 1394166-08-5
(Ε)-1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one

: 1394165-15-1
N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-4-oxo-1-(2-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / 2 h / 60 - 80 °C

2: acetonitrile / 10 h / 85 °C

3: trichlorophosphate / acetonitrile / 6 h / 85 °C

4: chlorobenzene / 30 h / 140 °C

5: ammonium chloride; iron / ethanol; water / 5 h / Reflux

6: triethylamine / dichloromethane / 10 h / 20 °C / Cooling with ice

With iron; ammonium chloride; triethylamine; trichlorophosphate; In ethanol; dichloromethane; water; acetic acid; chlorobenzene; acetonitrile;
DOI:10.1016/j.bmc.2013.04.013