methyl 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylate

Base Information

• Chemical Name: methyl 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylate
• CAS No.: 123342-05-2
• Molecular Formula: C₁₅H₁₅BrO₃S
• Molecular Weight: 355.252
• Mol file: 123342-05-2.mol

Synonyms:methyl 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylate

Chemical Property of methyl 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylate

There total 2 articles about methyl 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N,N’-diisopropyl-O-isopropylisourea (63460-32-2) + methyl 4-bromo-3-hydroxy-5-phenyl-2-thiophenecarboxylate (113589-27-8) → methyl 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylate (123342-05-2)

Guidance literature:

In acetonitrile; for 24h; Heating;

DOI:10.1021/jm00111a039

Reference yield:

3-Hydroxy-5-phenyl-thiophen-2-carbonsaeure-methylester (5556-23-0) → methyl 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylate (123342-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / bromine, acetic acid / 16 h / Ambient temperature

2: 90 percent / acetonitrile / 24 h / Heating

With bromine; acetic acid; In acetonitrile;

DOI:10.1021/jm00111a039

Reference yield: 98.0%

methyl 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylate (123342-05-2) → 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylic acid (113589-48-3)

Guidance literature:

With sodium hydroxide; In methanol; for 3h; Heating;

DOI:10.1021/jm00111a039

upstream raw materials:

N,N’-diisopropyl-O-isopropylisourea

methyl 4-bromo-3-hydroxy-5-phenyl-2-thiophenecarboxylate

3-Hydroxy-5-phenyl-thiophen-2-carbonsaeure-methylester

Downstream raw materials:

4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylic acid

4-bromo-3-(1-methylethoxy)-5-phenyl-N-1H-tetrazol-5-yl-2-thiophenecarboxamide