5556-23-0

Basic information

• Product Name: 3-Hydroxy-5-phenyl-2-thiophenecarboxylic acid methyl ester
• Synonyms: 3-Hydroxy-5-phenyl-2-thiophenecarboxylic acid methyl ester
• CAS NO: 5556-23-0
• Molecular Formula: C₁₂H₁₀O₃S
• Molecular Weight: 234.28
• Mol File: 5556-23-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Hydroxy-5-phenyl-2-thiophenecarboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-5-phenyl-2-thiophenecarboxylic acid methyl ester(5556-23-0)
• EPA Substance Registry System: 3-Hydroxy-5-phenyl-2-thiophenecarboxylic acid methyl ester(5556-23-0)

Safety Data

• Hazardous Substances Data: 5556-23-0(Hazardous Substances Data)

Usage

Description

3-Hydroxy-5-phenyl-2-thiophenecarboxylic acid methyl ester, also known as mocetinostat, is a synthetic hydroxamic acid derivative of thiophene carboxylic acid with potential pharmaceutical applications. As a histone deacetylase inhibitor, it can block enzymes that remove acetyl groups from histone proteins, potentially leading to changes in gene expression.

Uses

Used in Oncology:
3-Hydroxy-5-phenyl-2-thiophenecarboxylic acid methyl ester is used as an anticancer agent for the treatment of various cancers. It has shown promise in preclinical and clinical trials, modulating gene expression and exhibiting potential efficacy against different types of cancer.
Used in Neurodegenerative Disorders:
3-Hydroxy-5-phenyl-2-thiophenecarboxylic acid methyl ester is used as a potential therapeutic agent for neurodegenerative disorders. Its ability to modulate gene expression may contribute to the development of treatments for such conditions.
Used in HIV Treatment:
3-Hydroxy-5-phenyl-2-thiophenecarboxylic acid methyl ester is used as a potential treatment for HIV due to its ability to reactivate latent virus in infected cells, offering a novel approach to target and eliminate the virus.
Overall, 3-Hydroxy-5-phenyl-2-thiophenecarboxylic acid methyl ester is a compound with diverse potential applications in the field of medicine and pharmaceuticals, particularly in oncology, neurodegenerative disorders, and HIV treatment.

Upstream product

• 62-53-3 aniline 
• 4519-47-5 methyl 2-bromo-2-chloro-3-phenylpropanoate 
• 2365-48-2 Methyl thioglycolate 
• 24127-62-6 methyl 2-bromo-3-phenylacrylate 
• 103-26-4 methyl cinnamate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 637-44-5 phenylpropyolic acid 
• 87293-11-6 β-(Carboxymethylthio)-zimtsaeure 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 128775-92-8 methyl 2-chloro-5-phenyl-3-oxo-2,3-dihydrothiophene-2-carboxylate 
• 67-56-1 methanol 
• 109570-45-8 3,3-bis-carboxymethylsulfanyl-3-phenyl-propionic acid ethyl ester 

Downstream Products

• 50413-11-1 5-phenyl-3(2H)-thiophenone 
• 113588-88-8 4-bromo-3-(1-methylethoxy)-5-phenyl-N-1H-tetrazol-5-yl-2-thiophenecarboxamide 
• 113589-48-3 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylic acid 
• 123342-05-2 methyl 4-bromo-3-(1-methylethoxy)-5-phenyl-2-thiophenecarboxylate 
• 151824-96-3 3,4-Dihydro-6-phenyl-3-(2-tetrahydropyranyloxy)-2H-thieno-<2,3-e><1,3>oxazin-2,3-dion 
• 151824-92-9 3-Hydroxy-5-phenyl-N-(2-tetrahydropyranyloxy)thiophen-2-carboxamid 
• 886211-04-7 3-(2-oxo-propoxy)-5-phenyl-thiophene-2-carboxylic acid 
• 886211-01-4 3-(2-oxo-propoxy)-5-phenyl-thiophene-2-carboxylic acid methyl ester 
• 132864-56-3 3-Hydroxy-5-phenylthiophen-2-carbonsaeure 
• 144677-37-2 3-Hydroxy-5-phenyl-thiophene-2-carboxylic acid hydrazide; compound with hydrazine 
• 144677-19-0 5⁽³⁾-phenylpyrazol-3⁽⁵⁾-ylacetohydrazide 

Relevant articles and documents

Bromoarylation of Methyl 2-Chloroacrylate under Meerwein Conditions for the Synthesis of Substituted 3-Hydroxythiophenes

Methyl 3-aryl-2-bromo-2-chloropropanoates can be prepared by Meerwein reaction from methyl 2-chloroacrylate and various arenediazonium salts under copper(II) bromide catalysis. The resulting readily available compounds were used as starting materials in reactions with substituted methanethiols for the construction of substituted 3-hydroxythiophenes which have not yet been accessible by other routes. Structural variety of the obtained 2-substituted 5-aryl-3-hydroxythiophenes has been achieved due to a wide range of available starting materials, including both anilines and thiols.

N-1H-Tetrazol-5-yl-(5-Ring)-carboxamide-derivatives, a process for their manufacture, and the use thereof

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N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof

The present invention is for compounds having the formula of N-1H-tetrazol-5-yl-2-thiophenecarboxamides, N-1H-tetrazol-5-yl-2-pyrrolecarboxamides, N-1H-tetrazol-5-yl-2-furancarboxamides or analogs of each of the carboxamides. The compounds are useful for the treatment of allergic or inflammatory conditions or diseases. Thus, pharmaceutical compositions and methods of use are also the invention. Processes of preparation for the compounds are also the invention.