1-[((S)-2,6,6-trimethylcyclohex-2-enyl)methylsulfonyl]benzene

Base Information

• Chemical Name: 1-[((S)-2,6,6-trimethylcyclohex-2-enyl)methylsulfonyl]benzene
• CAS No.: 815581-82-9
• Molecular Formula: C₁₆H₂₂O₂S
• Molecular Weight: 278.415
• Mol file: 815581-82-9.mol

Synonyms:1-[((S)-2,6,6-trimethylcyclohex-2-enyl)methylsulfonyl]benzene

Chemical Property of 1-[((S)-2,6,6-trimethylcyclohex-2-enyl)methylsulfonyl]benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[((S)-2,6,6-trimethylcyclohex-2-enyl)methylsulfonyl]benzene

There total 11 articles about 1-[((S)-2,6,6-trimethylcyclohex-2-enyl)methylsulfonyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((S)-2,6,6-Trimethyl-cyclohex-2-enylmethylsulfanyl)-benzene (69297-41-2) → 1-[((S)-2,6,6-trimethylcyclohex-2-enyl)methylsulfonyl]benzene (815581-82-9)

Guidance literature:

With ammonium molibdate; dihydrogen peroxide; at 0 - 22 ℃;

DOI:10.1021/jo049012j

Reference yield:

[(1S,5R)-5-hydroxy-2,6,6-trimethylcyclohex-2-enyl]methyl 4-bromobenzoate (815581-77-2) → 1-[((S)-2,6,6-trimethylcyclohex-2-enyl)methylsulfonyl]benzene (815581-82-9)

Guidance literature:

Multi-step reaction with 6 steps

1: Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

2: 402 mg / DBU / toluene / 4 h / Heating

3: H₂ / Rh/Al₂O₃ / ethyl acetate / 24 h / 22 °C

4: 127 mg / NaOH / methanol / 2 h / 22 °C

5: n-Bu₃P / tetrahydrofuran / 0 - 22 °C

6: 77 mg / aq. H₂O₂; (NH₄)2MoO₄ / 0 - 22 °C

With ammonium molibdate; sodium hydroxide; tributylphosphine; hydrogen; dihydrogen peroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; Rh/Al₂O₃; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene;

DOI:10.1021/jo049012j

Reference yield:

[(R)-2,6,6-trimethylcyclohexa-2,4-dienyl]methyl 4-bromobenzoate (815581-78-3) → 1-[((S)-2,6,6-trimethylcyclohex-2-enyl)methylsulfonyl]benzene (815581-82-9)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Rh/Al₂O₃ / ethyl acetate / 24 h / 22 °C

2: 127 mg / NaOH / methanol / 2 h / 22 °C

3: n-Bu₃P / tetrahydrofuran / 0 - 22 °C

4: 77 mg / aq. H₂O₂; (NH₄)2MoO₄ / 0 - 22 °C

With ammonium molibdate; sodium hydroxide; tributylphosphine; hydrogen; dihydrogen peroxide; Rh/Al₂O₃; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1021/jo049012j

upstream raw materials:

((S)-2,6,6-Trimethyl-cyclohex-2-enylmethylsulfanyl)-benzene

[(R)-2,6,6-trimethylcyclohexa-2,4-dienyl]methyl 4-bromobenzoate

[(1S,5R)-5-hydroxy-2,6,6-trimethylcyclohex-2-enyl]methyl 4-bromobenzoate

4-Bromo-benzoic acid (1R,5S)-5-methanesulfonyloxy-2,6,6-trimethyl-cyclohex-2-enylmethyl ester

Downstream raw materials:

(S)-1-Benzenesulfonyl-3-(tert-butyl-diphenyl-silanyloxy)-1-((S)-2,6,6-trimethyl-cyclohex-2-enyl)-butan-2-ol

tert-Butyl-[(E)-(S)-1-methyl-3-((S)-2,6,6-trimethyl-cyclohex-2-enyl)-allyloxy]-diphenyl-silane

(3E)-4-[(S)-2,6,6-trimethylcyclohex-2-enyl]but-3-en-2-one

(S,3E)-4-[(S)-2,6,6-trimethylcyclohex-2-enyl]but-3-en-2-ol