N-(4-{4-[5-(2-methoxyethoxy)pyrazin-2-ylthio]-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Base Information

Chemical Name:N-(4-{4-[5-(2-methoxyethoxy)pyrazin-2-ylthio]-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide
CAS No.:1438638-83-5
Molecular Formula:C₂₄H₂₃N₅O₃S₂
Molecular Weight:493.61
Hs Code.:

Synonyms:N-(4-{4-[5-(2-methoxyethoxy)pyrazin-2-ylthio]-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Suppliers and Price of N-(4-{4-[5-(2-methoxyethoxy)pyrazin-2-ylthio]-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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TRC
N-[4-[4-[[5-(2-Methoxyethoxy)-2-pyrazinyl]thio]-2,6-dimethylphenyl]-2-thiazolyl]-4-pyridinecarboxamide
0.5mg
$ 145.00

Total 0 raw suppliers

Chemical Property of N-(4-{4-[5-(2-methoxyethoxy)pyrazin-2-ylthio]-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Chemical Property:

Purity/Quality:: N-[4-[4-[[5-(2-Methoxyethoxy)-2-pyrazinyl]thio]-2,6-dimethylphenyl]-2-thiazolyl]-4-pyridinecarboxamide ^*data from reagent suppliers

Safty Information:

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Useful:

Uses N-[4-[4-[[5-(2-Methoxyethoxy)-2-pyrazinyl]thio]-2,6-dimethylphenyl]-2-thiazolyl]-4-pyridinecarboxamide may be useful as a chemotherapeutic agent for neoplastic diseases.

Technology Process of N-(4-{4-[5-(2-methoxyethoxy)pyrazin-2-ylthio]-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

There total 3 articles about N-(4-{4-[5-(2-methoxyethoxy)pyrazin-2-ylthio]-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1439936-57-8
5-(2-methoxyethoxy)pyrazine-2-thiol

: N-[5-(4-iodo-2,6-dimethylphenyl)thiazol-2-yl]isonicotinamide

: 1438638-83-5
N-(4-{4-[5-(2-methoxyethoxy)pyrazin-2-ylthio]-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.112118

Reference yield: 59.0%

: 1334921-38-8
N-(4-(4-iodo-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide

: 1439936-57-8
5-(2-methoxyethoxy)pyrazine-2-thiol

: 1438638-83-5
N-(4-{4-[5-(2-methoxyethoxy)pyrazin-2-ylthio]-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 7h;

Reference yield:

: 1351523-79-9
2-bromo-5-(2-methoxyethoxy)pyrazine

: 1438638-83-5
N-(4-{4-[5-(2-methoxyethoxy)pyrazin-2-ylthio]-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 3 h / 80 °C

2: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 7 h / 100 °C

With copper(l) iodide; sodium monohydrogen sulfide x-hydrate; potassium carbonate; In N,N-dimethyl-formamide;