N-(4-{4-(5-(2-methoxyethoxy)pyrazin-2-ylsulfinyl)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Base Information

Chemical Name:N-(4-{4-(5-(2-methoxyethoxy)pyrazin-2-ylsulfinyl)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide
CAS No.:1439936-69-2
Molecular Formula:C₂₄H₂₃N₅O₄S₂
Molecular Weight:509.61
Hs Code.:

Synonyms:N-(4-{4-(5-(2-methoxyethoxy)pyrazin-2-ylsulfinyl)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

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Chemical Property of N-(4-{4-(5-(2-methoxyethoxy)pyrazin-2-ylsulfinyl)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

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Technology Process of N-(4-{4-(5-(2-methoxyethoxy)pyrazin-2-ylsulfinyl)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

There total 3 articles about N-(4-{4-(5-(2-methoxyethoxy)pyrazin-2-ylsulfinyl)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1438638-83-5
N-(4-{4-[5-(2-methoxyethoxy)pyrazin-2-ylthio]-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

: 1439936-69-2
N-(4-{4-(5-(2-methoxyethoxy)pyrazin-2-ylsulfinyl)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: With dihydrogen peroxide; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1351523-79-9
2-bromo-5-(2-methoxyethoxy)pyrazine

: 1439936-69-2
N-(4-{4-(5-(2-methoxyethoxy)pyrazin-2-ylsulfinyl)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 3 h / 80 °C

2: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 7 h / 100 °C

3: dihydrogen peroxide / dichloromethane / 16 h / 20 °C

With copper(l) iodide; sodium monohydrogen sulfide x-hydrate; dihydrogen peroxide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1439936-57-8
5-(2-methoxyethoxy)pyrazine-2-thiol

: 1439936-69-2
N-(4-{4-(5-(2-methoxyethoxy)pyrazin-2-ylsulfinyl)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 7 h / 100 °C

2: dihydrogen peroxide / dichloromethane / 16 h / 20 °C

With copper(l) iodide; dihydrogen peroxide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;