tert-butyl (4-carbamimidoylbenzyl)carbamate acetate salt

Base Information

• Chemical Name: tert-butyl (4-carbamimidoylbenzyl)carbamate acetate salt
• CAS No.: 217313-82-1
• Molecular Formula: C₂H₄O₂*C₁₃H₁₉N₃O₂
• Molecular Weight: 309.365
• Mol file: 217313-82-1.mol

Synonyms:tert-butyl (4-carbamimidoylbenzyl)carbamate acetate salt

Chemical Property of tert-butyl (4-carbamimidoylbenzyl)carbamate acetate salt

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of tert-butyl (4-carbamimidoylbenzyl)carbamate acetate salt

There total 4 articles about tert-butyl (4-carbamimidoylbenzyl)carbamate acetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl (Z)-4-(N’-hydroxycarbamimidoyl)benzylcarbamate + acetic acid (64-19-7,77671-22-8) → tert-butyl (4-carbamimidoylbenzyl)carbamate acetate salt (217313-82-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic anhydride;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (4-carbamimidoylbenzyl)carbamate acetate salt (217313-82-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 4 h / 90 °C / Inert atmosphere

3: acetic anhydride; palladium 10% on activated carbon; hydrogen

With palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; acetic anhydride; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile;

Reference yield:

tert-butyl N-[(4-cyanophenyl)methyl]carbamate (66389-80-8) → tert-butyl (4-carbamimidoylbenzyl)carbamate acetate salt (217313-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 4 h / 90 °C / Inert atmosphere

2: acetic anhydride; palladium 10% on activated carbon; hydrogen

With palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; acetic anhydride; N-ethyl-N,N-diisopropylamine; In methanol;

upstream raw materials:

Boc-4-acetylhydroxyamidinobenzylamide

acetic acid

di-tert-butyl dicarbonate

tert-butyl N-[(4-cyanophenyl)methyl]carbamate

Downstream raw materials:

4-amidinobenzylamine dihydrochloride

benzyl ((4-(((tert-butoxycarbonyl)amino)methyl)phenyl)(imino)methyl)carbamate