(1S,3S,4R)-2-[(S)-1-phenylethyl]-3-(benzylaminomethyl)-2-azabicyclo[2,2,1]heptane

Base Information

Chemical Name:(1S,3S,4R)-2-[(S)-1-phenylethyl]-3-(benzylaminomethyl)-2-azabicyclo[2,2,1]heptane
CAS No.:1290085-20-9
Molecular Formula:C₂₂H₂₈N₂
Molecular Weight:320.478
Hs Code.:

Synonyms:(1S,3S,4R)-2-[(S)-1-phenylethyl]-3-(benzylaminomethyl)-2-azabicyclo[2,2,1]heptane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,3S,4R)-2-[(S)-1-phenylethyl]-3-(benzylaminomethyl)-2-azabicyclo[2,2,1]heptane

Chemical Property:

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Technology Process of (1S,3S,4R)-2-[(S)-1-phenylethyl]-3-(benzylaminomethyl)-2-azabicyclo[2,2,1]heptane

There total 6 articles about (1S,3S,4R)-2-[(S)-1-phenylethyl]-3-(benzylaminomethyl)-2-azabicyclo[2,2,1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₆N₂

: 1290085-20-9
(1S,3S,4R)-2-[(S)-1-phenylethyl]-3-(benzylaminomethyl)-2-azabicyclo[2,2,1]heptane

Guidance literature:: With sodium tetrahydroborate; In methanol; for 2h;
DOI:10.1016/j.tetasy.2010.12.011

Reference yield:

: C₁₇H₂₃NO₂

: 1290085-20-9
(1S,3S,4R)-2-[(S)-1-phenylethyl]-3-(benzylaminomethyl)-2-azabicyclo[2,2,1]heptane

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride

2: ammonia; triphenylphosphine; diethylazodicarboxylate / toluene; benzene / Cooling with ice; Inert atmosphere

3: triphenylphosphine / methanol / Reflux

4: sodium sulfate / dichloromethane / 20 °C

5: sodium tetrahydroborate / methanol / 2 h

With sodium tetrahydroborate; lithium aluminium tetrahydride; ammonia; sodium sulfate; triphenylphosphine; diethylazodicarboxylate; In methanol; dichloromethane; toluene; benzene;
DOI:10.1016/j.tetasy.2010.12.011

Reference yield:

: 1290085-10-7
(1S,3S,4R)-2-[(S)-1-phenylethyl]-3-(azidomethyl)-2-azabicyclo[2,2,1]heptane

: 1290085-20-9
(1S,3S,4R)-2-[(S)-1-phenylethyl]-3-(benzylaminomethyl)-2-azabicyclo[2,2,1]heptane

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / methanol / Reflux

2: sodium sulfate / dichloromethane / 20 °C

3: sodium tetrahydroborate / methanol / 2 h

With sodium tetrahydroborate; sodium sulfate; triphenylphosphine; In methanol; dichloromethane;
DOI:10.1016/j.tetasy.2010.12.011