6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one

Base Information

• Chemical Name: 6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one
• CAS No.: 133496-69-2
• Molecular Formula: C₂₅H₂₈F₂N₂O₂
• Molecular Weight: 426.506
• Mol file: 133496-69-2.mol

Synonyms:6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one

Chemical Property of 6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one

There total 8 articles about 6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

3-(4-Fluoro-benzyl)-4-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-yl}-butyric acid methyl ester (133496-63-6) → 6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one (133496-69-2)

Guidance literature:

With PPA; at 130 ℃; for 5h;

DOI:10.1021/jm00111a046

Reference yield:

4-(3-Fluoro-benzyl)-dihydro-furan-2-one (133496-49-8) → 6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one (133496-69-2)

Guidance literature:

Multi-step reaction with 4 steps

1: glacial acetic acid, 33percent HBr-AcOH / 1.) RT, 15 min, 2.) 80 deg C, 4 h

2: diethyl ether

3: 85 percent / Na₂CO₃, KI / various solvent(s) / 20 h / Heating

4: 43 percent / polyphosphoric acid / 5 h / 130 °C

With PPA; hydrogen bromide; sodium carbonate; acetic acid; potassium iodide; In diethyl ether;

DOI:10.1021/jm00111a046

Reference yield:

3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid (133496-50-1) → 6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one (133496-69-2)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether

2: 85 percent / Na₂CO₃, KI / various solvent(s) / 20 h / Heating

3: 43 percent / polyphosphoric acid / 5 h / 130 °C

With PPA; sodium carbonate; potassium iodide; In diethyl ether;

DOI:10.1021/jm00111a046

upstream raw materials:

3-(4-Fluoro-benzyl)-4-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-yl}-butyric acid methyl ester

4-(3-Fluoro-benzyl)-dihydro-furan-2-one

3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid

3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid methyl ester