3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid methyl ester

Base Information

• Chemical Name: 3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid methyl ester
• CAS No.: 133496-74-9
• Molecular Formula: C₁₂H₁₄BrFO₂
• Molecular Weight: 289.144
• Mol file: 133496-74-9.mol

Synonyms:3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid methyl ester

Chemical Property of 3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid methyl ester

There total 1 articles about 3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3-Fluoro-benzyl)-dihydro-furan-2-one (133496-49-8) → 3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid methyl ester (133496-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: glacial acetic acid, 33percent HBr-AcOH / 1.) RT, 15 min, 2.) 80 deg C, 4 h

2: diethyl ether

With hydrogen bromide; acetic acid; In diethyl ether;

DOI:10.1021/jm00111a046

Reference yield: 85.0%

3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid methyl ester (133496-74-9) + 1-(4-fluorophenyl)-4-piperazinylbutanone (2560-31-8) → 3-(4-Fluoro-benzyl)-4-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-yl}-butyric acid methyl ester (133496-63-6)

Guidance literature:

With sodium carbonate; potassium iodide; In various solvent(s); for 20h; Heating;

DOI:10.1021/jm00111a046

Reference yield:

3-Bromomethyl-4-(4-fluoro-phenyl)-butyric acid methyl ester (133496-74-9) → 6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one (133496-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Na₂CO₃, KI / various solvent(s) / 20 h / Heating

2: 43 percent / polyphosphoric acid / 5 h / 130 °C

With PPA; sodium carbonate; potassium iodide; In various solvent(s);

DOI:10.1021/jm00111a046

upstream raw materials:

4-(3-Fluoro-benzyl)-dihydro-furan-2-one

Downstream raw materials:

3-(4-Fluoro-benzyl)-4-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-yl}-butyric acid methyl ester

6-Fluoro-3-{4-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one