tert-butyl (S)-1-benzyl-2-oxazepan-3-yl-3-bromopropylcarbamate

Base Information

Chemical Name:tert-butyl (S)-1-benzyl-2-oxazepan-3-yl-3-bromopropylcarbamate
CAS No.:918437-66-8
Molecular Formula:C₂₁H₃₁BrN₂O₃
Molecular Weight:439.393
Hs Code.:

Synonyms:tert-butyl (S)-1-benzyl-2-oxazepan-3-yl-3-bromopropylcarbamate

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Chemical Property of tert-butyl (S)-1-benzyl-2-oxazepan-3-yl-3-bromopropylcarbamate

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Technology Process of tert-butyl (S)-1-benzyl-2-oxazepan-3-yl-3-bromopropylcarbamate

There total 7 articles about tert-butyl (S)-1-benzyl-2-oxazepan-3-yl-3-bromopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 918437-79-3
(1-benzyl-2-oxo-azepan-3-yl)-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

: 918437-66-8
tert-butyl (S)-1-benzyl-2-oxazepan-3-yl-3-bromopropylcarbamate

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/ja0670761

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 918437-66-8
tert-butyl (S)-1-benzyl-2-oxazepan-3-yl-3-bromopropylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: 12.7 g / N-hydrosuccinimide; DCC / ethyl acetate / 5 h / 20 °C

2: 74 g / H₂ / Pd-C / ethyl acetate / 8 h

3: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C

4: HCl / ethyl acetate / 1.5 h / 20 °C

5: K₂CO₃; NaI / dimethylformamide / 2 h / 70 °C

6: 748 mg / diisopropylethylamine / CH₂Cl₂ / 11 h / 20 °C

7: 77 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 1 h / 0 °C

With Succinimide; hydrogenchloride; carbon tetrabromide; hydrogen; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja0670761

Reference yield:

: 1-benzyl-3-(3-hydroxy-propylamino)-azepan-2-one

: 918437-66-8
tert-butyl (S)-1-benzyl-2-oxazepan-3-yl-3-bromopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 748 mg / diisopropylethylamine / CH₂Cl₂ / 11 h / 20 °C

2: 77 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 1 h / 0 °C

With carbon tetrabromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane;
DOI:10.1021/ja0670761