1,7-Diazaspiro[4.6]undecane-1-carboxylic acid, 6-oxo-7-(phenylmethyl)-, 1,1-dimethylethyl ester, (5R)-

Base Information

Chemical Name:1,7-Diazaspiro[4.6]undecane-1-carboxylic acid, 6-oxo-7-(phenylmethyl)-, 1,1-dimethylethyl ester, (5R)-
CAS No.:918437-67-9
Molecular Formula:C21H30N2O3
Molecular Weight:358.481
Hs Code.:

Synonyms:

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Chemical Property of 1,7-Diazaspiro[4.6]undecane-1-carboxylic acid, 6-oxo-7-(phenylmethyl)-, 1,1-dimethylethyl ester, (5R)-

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1,7-Diazaspiro[4.6]undecane-1-carboxylic acid, 6-oxo-7-(phenylmethyl)-, 1,1-dimethylethyl ester, (5R)-

There total 10 articles about 1,7-Diazaspiro[4.6]undecane-1-carboxylic acid, 6-oxo-7-(phenylmethyl)-, 1,1-dimethylethyl ester, (5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 918437-66-8
tert-butyl (S)-1-benzyl-2-oxazepan-3-yl-3-bromopropylcarbamate

: 918437-67-9
7-benzyl-1-tert-butoxycarbonyl-1,7-diaza-spiro[4,6]undec-6-one

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/ja0670761

Reference yield:

: 1055423-27-2
(3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester

: 918437-67-9
7-benzyl-1-tert-butoxycarbonyl-1,7-diaza-spiro[4,6]undec-6-one

Guidance literature:: Multi-step reaction with 7 steps

1: 74 g / H₂ / Pd-C / ethyl acetate / 8 h

2: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C

3: HCl / ethyl acetate / 1.5 h / 20 °C

4: K₂CO₃; NaI / dimethylformamide / 2 h / 70 °C

5: 748 mg / diisopropylethylamine / CH₂Cl₂ / 11 h / 20 °C

6: 77 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 1 h / 0 °C

7: 72 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / 20 °C

With hydrogenchloride; carbon tetrabromide; hydrogen; sodium hexamethyldisilazane; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja0670761

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 918437-67-9
7-benzyl-1-tert-butoxycarbonyl-1,7-diaza-spiro[4,6]undec-6-one

Guidance literature:: Multi-step reaction with 8 steps

1: 12.7 g / N-hydrosuccinimide; DCC / ethyl acetate / 5 h / 20 °C

2: 74 g / H₂ / Pd-C / ethyl acetate / 8 h

3: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C

4: HCl / ethyl acetate / 1.5 h / 20 °C

5: K₂CO₃; NaI / dimethylformamide / 2 h / 70 °C

6: 748 mg / diisopropylethylamine / CH₂Cl₂ / 11 h / 20 °C

7: 77 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 1 h / 0 °C

8: 72 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / 20 °C

With Succinimide; hydrogenchloride; carbon tetrabromide; hydrogen; sodium hexamethyldisilazane; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja0670761