5-cyclopropyl-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-2-(4-methoxyphenyl)-N-methyl-2H-indazole-3-carboxamide

Base Information

Chemical Name:5-cyclopropyl-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-2-(4-methoxyphenyl)-N-methyl-2H-indazole-3-carboxamide
CAS No.:1373839-88-3
Molecular Formula:C₂₃H₂₈N₄O₅S
Molecular Weight:472.565
Hs Code.:

Synonyms:5-cyclopropyl-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-2-(4-methoxyphenyl)-N-methyl-2H-indazole-3-carboxamide

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Chemical Property of 5-cyclopropyl-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-2-(4-methoxyphenyl)-N-methyl-2H-indazole-3-carboxamide

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Technology Process of 5-cyclopropyl-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-2-(4-methoxyphenyl)-N-methyl-2H-indazole-3-carboxamide

There total 11 articles about 5-cyclopropyl-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-2-(4-methoxyphenyl)-N-methyl-2H-indazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373844-78-0
5-cyclopropyl-2-(4-hydroxyphenyl)-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-N-methyl-2H-indazole-3-carboxamide

: 74-88-4
methyl iodide

: 1373839-88-3
5-cyclopropyl-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-2-(4-methoxyphenyl)-N-methyl-2H-indazole-3-carboxamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 0.75h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1373839-88-3
5-cyclopropyl-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-2-(4-methoxyphenyl)-N-methyl-2H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: nitric acid; sulfuric acid / 0.42 h / cooling with ice

2.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 6 h / Inert atmosphere; Reflux

4.1: acetic acid / 60 °C

4.2: 0.08 h / 60 °C

5.1: phosphorus trichloride / chloroform / 1 h / 60 °C

6.1: sodium hydroxide; water / ethanol / 15 h / 90 °C

7.1: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C

8.1: water; ammonium chloride; iron / ethanol / 1.5 h / 80 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

10.1: potassium carbonate / acetonitrile / 16 h / 80 °C

11.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

12.1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 60 °C

With pyridine; sulfuric acid; water; nitric acid; iron; sodium carbonate; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; trichlorophosphate; phosphorus trichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile; 3.1: Suzuki Coupling;

Reference yield:

: 1373844-53-1
2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carbonitrile

: 1373839-88-3
5-cyclopropyl-6-[(3-hydroxypropyl)(methylsulfonyl)amino]-2-(4-methoxyphenyl)-N-methyl-2H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide; water / ethanol / 15 h / 90 °C

2: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C

3: water; ammonium chloride; iron / ethanol / 1.5 h / 80 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

5: potassium carbonate / acetonitrile / 16 h / 80 °C

6: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

7: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 60 °C

With pyridine; water; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;