tert-butyl 4-[(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate
CAS No.:1346151-39-0
Molecular Formula:C₁₉H₂₆N₂O₅
Molecular Weight:362.426
Hs Code.:

Synonyms:tert-butyl 4-[(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-[(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate

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Technology Process of tert-butyl 4-[(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate

There total 1 articles about tert-butyl 4-[(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6272-26-0
6-hydroxybenzofuran-3-one

: 1346151-39-0
tert-butyl 4-[(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 4 h / 120 °C / Reflux; Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / toluene / 5 h / 110 °C / Inert atmosphere

With triphenylphosphine; diethylazodicarboxylate; In ethanol; toluene; 1: Mannich reaction / 2: Mitsunobu reaction;
DOI:10.1021/jm3001289

Reference yield: 55.0%

: 50562-79-3
1-(4-tolylsulfonyl)indole-3-carboxaldehyde

: 1346151-39-0
tert-butyl 4-[(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate

: 1346151-60-7
tert-butyl (Z)-4-({6-methoxy-3-oxo-2-[(1-tosyl-1H-indol-3-yl)methylene]-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate

Guidance literature:: With piperidine; In methanol; at 60 ℃; for 2h;

Reference yield:

: 1346151-39-0
tert-butyl 4-[(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate

: C₃₃H₃₄N₄O₅

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / methanol / 2 h / 60 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 0.17 h / 140 °C / Microwave irradiation

With piperidine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In methanol; 1,2-dimethoxyethane; water; 1: |Knoevenagel Condensation / 2: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.6b00518