1-[5-(amino-phenyl-methyl)-tetrazol-1-yl]-3-(tert-butyldiphenyl-silanyloxy)-propan-2-ol

Base Information

• Chemical Name: 1-[5-(amino-phenyl-methyl)-tetrazol-1-yl]-3-(tert-butyldiphenyl-silanyloxy)-propan-2-ol
• CAS No.: 1187063-66-6
• Molecular Formula: C₂₇H₃₃N₅O₂Si
• Molecular Weight: 487.677

Synonyms:1-[5-(amino-phenyl-methyl)-tetrazol-1-yl]-3-(tert-butyldiphenyl-silanyloxy)-propan-2-ol

Chemical Property of 1-[5-(amino-phenyl-methyl)-tetrazol-1-yl]-3-(tert-butyldiphenyl-silanyloxy)-propan-2-ol

Chemical Property:

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Technology Process of 1-[5-(amino-phenyl-methyl)-tetrazol-1-yl]-3-(tert-butyldiphenyl-silanyloxy)-propan-2-ol

There total 1 articles about 1-[5-(amino-phenyl-methyl)-tetrazol-1-yl]-3-(tert-butyldiphenyl-silanyloxy)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-8-azido-6-(tert-butyl-diphenyl-silanyloxymethyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine (1187063-50-8) → 1-[5-(amino-phenyl-methyl)-tetrazol-1-yl]-3-(tert-butyldiphenyl-silanyloxy)-propan-2-ol (1187063-68-8) + 1-[5-(amino-phenyl-methyl)-tetrazol-1-yl]-3-(tert-butyldiphenyl-silanyloxy)-propan-2-ol (1187063-66-6)

Guidance literature:

With methanol; magnesium; for 12h; optical yield given as %de; diastereoselective reaction;

DOI:10.1016/j.tet.2009.06.033

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-[5-(amino-phenyl-methyl)-tetrazol-1-yl]-3-(tert-butyldiphenyl-silanyloxy)-propan-2-ol (1187063-66-6) → ({1-[3-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-propyl]-1H-tetrazol-5-yl}-phenyl-methyl)-carbamic acid tert-butyl ester (1187063-71-3)

Guidance literature:

With triethylamine; In methanol; at 30 ℃; for 2h;

DOI:10.1016/j.tet.2009.06.033

upstream raw materials:

cis-8-azido-6-(tert-butyl-diphenyl-silanyloxymethyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine

Downstream raw materials:

({1-[3-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-propyl]-1H-tetrazol-5-yl}-phenyl-methyl)-carbamic acid tert-butyl ester

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