tert-butyl α-<(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetate

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Chemical Name:tert-butyl α-<(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetate
CAS No.:110221-35-7
Molecular Formula:C₂₉H₃₈N₂O₅S
Molecular Weight:526.697
Hs Code.:

Synonyms:tert-butyl α-<(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetate

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Chemical Property of tert-butyl α-<(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetate

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Technology Process of tert-butyl α-<(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetate

There total 12 articles about tert-butyl α-<(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 110143-56-1
(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2-phenylperhydro-1,4-thiazepin-5-one

: 110221-35-7
tert-butyl α-<(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 5h; Ambient temperature;
DOI:10.1021/jm00394a009

Reference yield:

: 90315-82-5
ethyl (R)-2-hydroxy-4-phenylbutyrate

: 110221-35-7
tert-butyl α-<(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 97 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: 97 percent / NaH / dimethylformamide / 5 h / Ambient temperature

With pyridine; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a009

Reference yield:

: 5153-67-3
nitrostyrene

: 110221-35-7
tert-butyl α-<(2R,6R)-6-<<(S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-5-oxo-2-phenylperhydro-1,4-thiazepin-4-yl>acetate

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / toluene / 16 h / Ambient temperature

2: 51 percent / H₂, AcOH / 5percent Pd/C / 5 h / 70 °C / 2280 Torr

3: 78 percent / diphenyl phosphorazidate, N-methylmorpholine / dimethylformamide / 16 h / Ambient temperature

4: 4 N aq. HCl / dioxane / 4 h / Ambient temperature

5: 97 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

6: 97 percent / NaH / dimethylformamide / 5 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; diphenyl phosphoryl azide; hydrogen; sodium hydride; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00394a009