3,5-bis(trifluoromethyl)phenyl 4-(dimethylamino)benzenesulfonate

Base Information

• Chemical Name: 3,5-bis(trifluoromethyl)phenyl 4-(dimethylamino)benzenesulfonate
• CAS No.: 1221970-98-4
• Molecular Formula: C₁₆H₁₃F₆NO₃S
• Molecular Weight: 413.341
• Mol file: 1221970-98-4.mol

Synonyms:3,5-bis(trifluoromethyl)phenyl 4-(dimethylamino)benzenesulfonate

Chemical Property of 3,5-bis(trifluoromethyl)phenyl 4-(dimethylamino)benzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-bis(trifluoromethyl)phenyl 4-(dimethylamino)benzenesulfonate

There total 1 articles about 3,5-bis(trifluoromethyl)phenyl 4-(dimethylamino)benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3,5-bis-(trifluoromethyl)phenol (349-58-6) + 4-(dimethylamino)benzenesulfonyl chloride (19715-49-2) → 3,5-bis(trifluoromethyl)phenyl 4-(dimethylamino)benzenesulfonate (1221970-98-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1002/anie.200905379

Reference yield: 71.0%

3,5-bis(trifluoromethyl)phenyl 4-(dimethylamino)benzenesulfonate (1221970-98-4) + benzoyl chloride (98-88-4) → [3,5-bis(trifluoromethyl)phenyl](phenyl)methanone (21221-93-2)

Guidance literature:

3,5-bis(trifluoromethyl)phenyl 4-(dimethylamino)benzenesulfonate; With para-fluorostyrene; copper(I) cyanide di(lithium chloride); phenylmagnesium chloride; tetra-(n-butyl)ammonium iodide; cobalt acetylacetonate; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; at -20 - 25 ℃; Inert atmosphere;

benzoyl chloride; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; at -20 - 25 ℃; for 2.5h; Inert atmosphere;

DOI:10.1002/anie.200905379

Reference yield: 71.0%

3,5-bis(trifluoromethyl)phenyl 4-(dimethylamino)benzenesulfonate (1221970-98-4) + ethyl 2-bromomethyl-2-propenoate (17435-72-2) → ethyl 2-(3,5-bis(trifluoromethyl)benzyl)acrylate (1221971-03-4)

Guidance literature:

3,5-bis(trifluoromethyl)phenyl 4-(dimethylamino)benzenesulfonate; With para-fluorostyrene; copper(I) cyanide di(lithium chloride); phenylmagnesium chloride; tetra-(n-butyl)ammonium iodide; cobalt acetylacetonate; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; at -20 - 25 ℃; Inert atmosphere;

ethyl 2-bromomethyl-2-propenoate; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; at -20 - 25 ℃; for 2.5h; Inert atmosphere;

DOI:10.1002/anie.200905379

upstream raw materials:

3,5-bis-(trifluoromethyl)phenol

4-(dimethylamino)benzenesulfonyl chloride

Downstream raw materials:

[3,5-bis(trifluoromethyl)phenyl](phenyl)methanone

ethyl 2-(3,5-bis(trifluoromethyl)benzyl)acrylate