3-(phenylsulfonyl)-4-phenyl-5-(methoxycarbonyl)-3a,4,5,7a-tetrahydropyrido<3,4-d>isoxazole

Base Information

• Chemical Name: 3-(phenylsulfonyl)-4-phenyl-5-(methoxycarbonyl)-3a,4,5,7a-tetrahydropyrido<3,4-d>isoxazole
• CAS No.: 87843-06-9
• Molecular Formula: C₂₀H₁₈N₂O₅S
• Molecular Weight: 398.439

Synonyms:3-(phenylsulfonyl)-4-phenyl-5-(methoxycarbonyl)-3a,4,5,7a-tetrahydropyrido<3,4-d>isoxazole

Chemical Property of 3-(phenylsulfonyl)-4-phenyl-5-(methoxycarbonyl)-3a,4,5,7a-tetrahydropyrido<3,4-d>isoxazole

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 3-(phenylsulfonyl)-4-phenyl-5-(methoxycarbonyl)-3a,4,5,7a-tetrahydropyrido<3,4-d>isoxazole

There total 2 articles about 3-(phenylsulfonyl)-4-phenyl-5-(methoxycarbonyl)-3a,4,5,7a-tetrahydropyrido<3,4-d>isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.4%

bromo(phenylsulfonyl)formaldoxime (70367-23-6) + N-(methoxycarbonyl)-2-phenyl-1,2-dihydropyridine (54732-59-1) → 3-(phenylsulfonyl)-4-phenyl-5-(methoxycarbonyl)-3a,4,5,7a-tetrahydropyrido<3,4-d>isoxazole (87843-06-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; 1.) 0 deg C, 2.) 24 h, 25 deg C;

DOI:10.1021/jo00175a025

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + phenylsulfonylnitromethane (21272-85-5) + N-(methoxycarbonyl)-2-phenyl-1,2-dihydropyridine (54732-59-1) → 3-(phenylsulfonyl)-4-phenyl-5-(methoxycarbonyl)-3a,4,5,7a-tetrahydropyrido<3,4-d>isoxazole (87843-06-9)

Guidance literature:

With sodium silicate; Yield given. Multistep reaction; 1.) methylene chloride, 30 min, cooling, 2.) 12 h, reflux;

DOI:10.1021/jo00175a025

Reference yield: 17.4%

3-(phenylsulfonyl)-4-phenyl-5-(methoxycarbonyl)-3a,4,5,7a-tetrahydropyrido<3,4-d>isoxazole (87843-06-9) → cis-1-(methoxycarbonyl)-2-phenyl-3-cyano-4-hydroxy-1,2,3,4-tetrahydropyridine (87843-14-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃;

DOI:10.1021/jo00175a025

upstream raw materials:

diazomethane

phenylsulfonylnitromethane

N-(methoxycarbonyl)-2-phenyl-1,2-dihydropyridine

bromo(phenylsulfonyl)formaldoxime

Downstream raw materials:

cis-1-(methoxycarbonyl)-2-phenyl-3-cyano-4-hydroxy-1,2,3,4-tetrahydropyridine

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