tert-butyl (±)-4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-hydroxy-3-(4-methoxyphenyl)butanoate

Base Information

Chemical Name:tert-butyl (±)-4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-hydroxy-3-(4-methoxyphenyl)butanoate
CAS No.:1646145-90-5
Molecular Formula:C₂₁H₂₈O₇
Molecular Weight:392.449
Hs Code.:

Synonyms:tert-butyl (±)-4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-hydroxy-3-(4-methoxyphenyl)butanoate

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Chemical Property of tert-butyl (±)-4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-hydroxy-3-(4-methoxyphenyl)butanoate

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Technology Process of tert-butyl (±)-4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-hydroxy-3-(4-methoxyphenyl)butanoate

There total 1 articles about tert-butyl (±)-4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-hydroxy-3-(4-methoxyphenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 540-88-5
acetic acid tert-butyl ester

: 1332372-74-3
6-(2-(4-methoxyphenyl)-2-oxoethyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

: 1646145-90-5
tert-butyl (±)-4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-hydroxy-3-(4-methoxyphenyl)butanoate

Guidance literature:: acetic acid tert-butyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

6-(2-(4-methoxyphenyl)-2-oxoethyl)-2,2-dimethyl-4H-1,3-dioxin-4-one; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201402473

Reference yield:

: 1646145-90-5
tert-butyl (±)-4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-hydroxy-3-(4-methoxyphenyl)butanoate

: 1646145-84-7
tert-butyl 4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-(4-methoxyphenyl)but-2-enoate

: C₂₁H₂₆O₆

Guidance literature:: With Burgess Reagent; In acetonitrile; at 70 ℃; for 4h; Overall yield = 81 %; Overall yield = 376 g; Inert atmosphere;
DOI:10.1002/ejoc.201402473