1332372-74-3

Upstream product

• 10364-93-9 1-(4-methoxybenzoyl)-imidazole 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 100-09-4 4-methoxybenzoic acid 
• 4231-69-0 1-(4-methoxybenzoyl)-1H-1,2,3-benzotriazole 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 1332372-80-1 C₁₅H₁₇NO₄ 
• 1646145-90-5 tert-butyl (±)-4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-hydroxy-3-(4-methoxyphenyl)butanoate 
• 1646145-84-7 tert-butyl 4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-(4-methoxyphenyl)but-2-enoate 
• 1646145-73-4 (±)-4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-hydroxy-3-(4-methoxyphenyl)butanoic acid 
• 1293991-74-8 (Z)-3-(3-hydroxy-3-(4-methoxyphenyl)acryloyl)-6,6,9a-trimethyl-5,6-dihydro-2H-furo[3,2-g]isochromene-2,9(9aH)-dione 

Relevant academic research and scientific papers

A Biocatalytic Route to Highly Enantioenriched β-Hydroxydioxinones

A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in acc

Palladium-Catalyzed Carbonylative Couplings of Vinylogous Enolates: Application to Statin Structures

The first Pd-catalyzed carbonylative couplings of aryl and vinyl halides with vinylogous enolates are reported generating products derived from C-C bond formation exclusively at the γ-position. Good results were obtained with a dienolate derivative of acetoacetate (1,3-dioxin-4-one). These transformations occurred at room temperature and importantly with only stoichiometric carbon monoxide in a two-chamber reactor. The methodology was applied to the synthesis of two members of the statin family generating the cis-3,5-diol acid motif by a γ-selective carbonylation followed by a cis-stereoselective reduction of the 3,5-dicarbonyl acid intermediates.

Design and synthesis of epicocconone analogues with improved fluorescence properties

Epicocconone is a natural latent fluorophore that is widely used in biotechnology because of its large Stokes shift and lack of fluorescence in its unconjugated state. However, the low photostability and quantum yields of epicocconone have limited its wid

Synthesis of 6-substituted-4-hydroxy-2-pyridinones via intramolecular ketene trapping of functionalized enamine-dioxinones

The synthesis of various 6-substituted-4-hydroxy-2-pyridinones is reported. The functionalized keto-dioxinones were constructed via a diethylzinc mediated crossed Claisen condensation reaction and subsequent enamine formation, thermolysis, and cyclization