4-methyl-1-[2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]piperidine

Base Information

Chemical Name:4-methyl-1-[2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]piperidine
CAS No.:1245612-68-3
Molecular Formula:C₁₆H₁₈F₃N₃S
Molecular Weight:341.4
Hs Code.:

Synonyms:4-methyl-1-[2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-methyl-1-[2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]piperidine

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Technology Process of 4-methyl-1-[2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]piperidine

There total 3 articles about 4-methyl-1-[2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1245612-67-2
2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea

: 1245612-68-3
4-methyl-1-[2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]piperidine

Guidance literature:: With Lawessons reagent; In 1,2-dimethoxyethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.10.052

Reference yield:

: 1245612-67-2
2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea

: 1245612-68-3
4-methyl-1-[2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]piperidine

Guidance literature:: 2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea; With Lawessons reagent; In 1,2-dimethoxyethane; at 20 ℃;

With sodium hydroxide; In water; for 0.5h;

Reference yield:

: 206761-91-3
1,3,5-trifluoro-2-isothiocyanatobenzene

: 1245612-68-3
4-methyl-1-[2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

3: Lawessons reagent / 1,2-dimethoxyethane / 16 h / 20 °C / Inert atmosphere

With Lawessons reagent; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2012.10.052