2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea

Base Information

Chemical Name:2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea
CAS No.:1245612-67-2
Molecular Formula:C₁₆H₂₀F₃N₃OS
Molecular Weight:359.416
Hs Code.:

Synonyms:2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea

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Chemical Property of 2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea

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Technology Process of 2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea

There total 4 articles about 2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1245612-66-1
1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea

: 74-88-4
methyl iodide

: 1245612-67-2
2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.10.052

Reference yield:

: 1245612-66-1
1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea

: 74-88-4
methyl iodide

: 1245612-67-2
2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 1h;

Reference yield:

: 206761-91-3
1,3,5-trifluoro-2-isothiocyanatobenzene

: 1245612-67-2
2-methyl-1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)isothiourea

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2012.10.052